Department of Pathology
Yamaguchi University Graduate School of Medicine
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Publications (Papers wirtten in English)


* Click on authors' name to read abstract of the paper


-2011-

Oga A, Uchida K, Nakao M, Kawauchi S, Furuya T, Chochi Y, Ikemoto K, Okada T, Ueyama Y, Sasaki K, Yousefpour F.
Loss of 6q or 8p23 is associated with the total number of DNA copy number aberrations in adenoid cystic carcinoma.
Oncology Rep 2011 Sep 5. doi: 10.3892/or.2011.1446. [Epub ahead print]



Uchida K, Oga A, Nakao M, Mano T, Mihara M, Kawauchi S, Furuya T, Ueyama Y, Sasaki K.
Loss of 3p26.3 is an independent prognostic factor in patients with oralsquamous cellcarcinoma.
Oncology Rep 2011; 26: 463-469.



Nakao M, Kawauchi S, Uchiyama T, Adach J, Ito H, Chochi Y, Furuya T, Oga A, Sasaki K.
DNA copy number aberrations associated with the clinicopathological features of colorectal cancers: Odentification of genomic biomarkers by array-based comparative genomic hybridization.
Oncol Rep 2011; 25: 1603-1611.



Xu JD, Cao XX, Long ZW, Liu XP, Furuya T, Xu Z, Sasaki k, Li QQ
BCL2L10 protein regulates apoptosis/proliferation through differential pathways in gastric cancer cells.
J Pathol. 2011 Feb;223(3):400-9.



 -2010-

Xu JD, Furuya T, Cao XX, Liu XL, Li QQ, Wang WJ, Xu ZD, SasakiK, Liu XP
Loss of BCL2L10 protein expression as prognostic predictor for poor clinical outcome in gastric carcinoma.
Histopathology. 2010 Dec;57(6):814-24.


Uchida K, Oga A, Mano T, Nagatsuka H, Ueyama Y, Sasaki K.
Screening for DNA copy number aberrations in mucinous adenocarcinoma arising from the minor salivary gland: two case reports
Cancer Genetics and Cytogenetics 2010; 203: 324-327

Kawauchi S, Furuya T, Ikemoto K, Nakao M, Yamamoto S, Oka M, Sasaki K.

DNA copy number aberrations associated with aneuploidy and chromosomal instability in breast cancers.
Oncology Rep 2010; 24:875-883

Kawauchi S, Furuya T, Uchiyama T, Adachi A, Okada T, Nakao M, Oga A, Uchida K, Sasaki K.
Genomic instability and DNA ploidy are linked to DNA copy number aberrations of 8p23 and 22q11.23 in gastric cancers.
International Journal of Molecular Medicine 2010; 26: 333-339

Eguchi S, Yanmamoto Y, Sakano S, Chochi Y, Nakano M, Kawauchi S, Furuya T, Oga A, Matsuyma H, Sasaki K.
The loss of 8p23.3 is a novel marker for predicting progression and recurrence of bladder tumors without muscle invasion.
Cancer Genet Cytogenet. 2010 Jul 1; 200(1):16-22

Tsuji K, Kawauchi S, Saito S, Furuya T, Ikemoto K, Nakao M, Yamamoto S, Oka M, Hirano T, Sasaki K.
Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: Comparison of the CGH profiles between cancer cell lines and primary cancer tissues
BMC Cancer 2010, 10:15 (14 January 2010)

Kawauchi S, Furuya T, Nakao M, Ikemoto K Oga A, Sasaki K.
A simple method for enhancing hybidization efficiency in chromosome and array comparative genomic hybridization.
Biotech Histochem. 2010 Mar 16. [Epub ahead of print]

Misumi T, Yamamoto Y, Murakami T Kawai Y, Ito H, Eguchi S, Yano S, Nagao K, Hara T, Sakano S, Naito K, Sasaki K, Fuellhase C, Arenas L, Fichtner J, Matsuyama H.
Genetic Alterations at 13q14 May Correlate with Differences in the Biological Behavior of Prostate Cancer between Japanese and Caucasian Men.
Urol Int. 2010; 84(4): 461-6

Kawauchi S, Nawata H, Yamagata Y, Yaegashi H, Fukunaga M, Moriya T, Furuya T, Sugino N, Sasaki K.
Chromosomal imbalances detected by comparative genomic hybridization provide evidence that HMB-45-negative uterine anginomyolipomas belong to the PEComa family
Histopathology 2010; 56(7): 974-977

XuJD, Furuya T, Cao XX, Liu XL, LiQQ Wang WJ, Xu ZD, Sasaki K and Liu XP.
Loss of BCL2L10 protein expression as a prognostic predictor for poor clinical outcome in gastric carcinoma.
Histopathology

Liu XL, Furuya T, Li DY, Xu JD, Cao XX, LiQQ, Xu JW, XuZD, Sasaki K and LiuXP.
Cx26 expression correlates with less aggerssive phenotype of intestinal type-gastric carcinomas,
Int J Mol Med. 2010 May;25(5):709-16


    -2009-

Nakao M, Uchiyama T, Adachi J, uruya T, Oga A, Kawauchi S, Sasaki K.
The Development of a Variable Threshold Analysis Method to Identify Clones Linked the Clinicopathological Features in an Array-Based CGH-Its Application to Colorectal Cancer.
Bull Yamaguchi Med Sch. 2009; 56: 43-48
Nakao M, Sasaki K.
Identification of the copy Number Aberrations for Determining the Disease Stage of Colorectal Cancers: The Application of a Multifactor Dimensionality Reduction (MDR) Method to an Array-Based CGH.
Bull Yamaguchi Med Sch. 2009; 56: 49-55
Kawauchi S, Sakai H, Ikemoto K, Eguchi S, Nakao M, Takihara H, Shimabukuro T, Furuya T, Oga A, Matsuyama H, Takahashi M, Sasaki K.
9p21 index as estimated by dual-color fluorescence in situ hybridization is useful to predict urothelial carcinoma recurrence in bladder washing cytology.
Hum Pathol. 2009; 40(12): 1783-9
Yamamoto Y, Eguchi S, Akao J, Nagao K, Sakano S, Furuya T, Oga A, Kawauchi S, Sasaki K, Matsuyama H.
Intercellular centrosome number is correlated with the copy number of chromosomes in bladder cancer.
Cancer Genet Cytogenet. 2009; 191(1): 38-42.

Yamagata Y, Kawauchi S, Tamura H, Murakami A, Sasaki K, Sugino N.
A Case of HMB45-negative perivascular epitheloid cell tumor (PEComa) of the uterine corpus: A possible diagnostic application of molecular- cytogenetic analysis.

EurJ Gynaec Oncol 2009; 30: 216-219.

Matsuyama H, Yamamoto Y, Nagao K, Ohmi C, Sakano S, Sasaki K.
Cytogenetic analysis of false-positive mucosa by photodynamic diagnosis using 5-aminolevulinic acid-possible existence of premalignant genomic alterations examined by in vitro experiment.
Oncology. 2009; 76(2): 118-25.


-2008-

Suehiro Y, Okada T, Okada T, Anno K, Okayama N, Ueno K, Hiura M, Nakamura M, Kondo T, Oga A, kawauchi S, Hirabayashi K, Numa F, Ito T, Saito T, Sasaki K, Hinoda Y.
Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation.
Clinical Cancer Research 2008; Jun 1;14(11):3354-61

Kawauchi S, Furuya T, Nakao M, Ikemoto K, Oga A, Sasaki K.
A simple method for enhancing hybridization efficiency in chromosome and array comparative genomic hybridization.
BIOTECHNIC & HISTOCHEMISTRY 2009 (In press)

Kawauchi S, Kusuda T. Liu XP. Suehiro Y. Kaku T. Mikami Y. Takeshita M. Nakao M. Chochi Y. Sasaki K.

Is Lobular Endocervical Glandular Hyperplasia a Cancerous Precursor of Minimal Deviation Adenocarcinoma? : A Comparative Molecular-Genetic and Immunohistochemical Study.
Am J Surg Pathol. 2008 Dec;32(12):1807-1815


Furuya T, Uchiyma T, Adachi A, Okada T, Nakao M, Oga A, Kawauchi S, Kang JJ, Yang S-J, Sasaki K.
The development of a mini-array for estimating the disease states of gastric adenocarcinoma by array CGH.
BMC Cancer 2008, 8:393 (30 December 2008)


Nakao M, Kawauchi S, Furuya T, Uchiyama T, Adachi J, Okada T, Ikemoto K, Oga A, Sasaki K.
Identification of DNA copy number aberrations associated with metastases of colorectal cancer using array CGH profiles.
Cancer Genet Cytogenet 2009; 181(2): 70-76


Chochi Y, Kawauchi S, Nakao M, Furuya T, Hashimoto K, Oga A, Oka M, and Sasaki K.
A copy Number gain of the 6p arm is linked with advanced hepatocellular carcinoma.
J Pathol 2008; 9:16AM



Liu XP, Li DY, Xu JD, Furuya T, Kawauchi S, Oga A, Sasaki K.
Comparison of chromosomal aberrations between primary tumors and their synchronous lymph-node metastases in intestinal-type gastric carcinoma.
Pathol Res Pract. 2008 Nov 26. [Epub ahead of print]



-2007-


Kawauchi S, Sugimoto S, Liu XP, Ikemoto K, Furuya T, Takahashi M, Sasaki K.

Influence of cytological stains on comparative genomic hybridization analysis for DNA extracted from cytological smears.
Oncol Rep. 2007 Nov;18(5):1219-23
.

Yamamoto, Y. Chochi, Y. Matsuyama, H. Eguchi, S. Kawauchi, S. Furuya, T. Oga, A. Kang, J.J. Naito, K. Sasaki, K.
Gain of 5p15.33 Is Associated with Progression of Bladder Cancer
Oncology 2007;72:132-138 (DOI:10.1159/000111132) 
 


Yamamoto Y, Matsuyama H, Chochi Y, Okuda M, Kawauchi S, Inoue R, Furuya T, Oga A, Naito K, Sasaki K.
Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer.
Cancer Genet Cytogenet. 2007 Apr 1;174(1):42-7.


Matsuyama H, Oba K, Matsuda K, Yoshihiro S, Tsukamoto M, Kinjo M, Sagiyama K, Takei M, Yamaguchi A, Sasaki K, Naito K.
Haploinsufficiency of 8p22 may influence cancer-specific survival in prostate cancer.
Cancer Genet Cytogenet. 2007 Apr 1;174(1):24-34
.

Liu XP, Kawauchi S, Oga A, Sato T, Ikemoto K, Ikeda E, Sasaki K.
Chromosomal aberrations detected by comparative genomic hybridization predict outcome in patients with colorectal carcinoma.
Oncol Rep. 2007 Jan;17(1):261-7.

-2006-


Nakao M, Okada T, Ikemoto K, Furuya T, Oga A, Kawauchi S, Sasaki K
The Development of a Novel Method for the Classification of the aCGH
Profiles Based on Genomic Alterations. Bull Yamaguchi Med Sch
2006;53.:37 - 43


Akao J, Matsuyama H, Yamamoto Y, Sasaki K, Naito K.
Chromosome 20q13.2 gain may predict intravesical recurrence after nephroureterectomy in upper urinary tract urothelial tumors.
Clin Cancer Res. 2006 ;12(23):7004-8
.

Kawauchi S, Yamamoto Y, Uchida K, Chochi Y, Kondo T, Oga A, Sasaki K.
Significance of cyclin E and p27 expression in malignant ovarian germ cell tumors: Correlation with the cell proliferation activity and clinicopathologic features.
Oncol Rep. Nov;16(5):1029-33


Toshimitsu H, Iizuka N, Yamamoto K, Kawauchi S, Oga A, Furuya T, Oka M, Sasaki K.
Molecular features linked to the growth-ingibitory effects of gemcitabine on human pancreatic cancer cells
Oncology Report Dec;16(6):1285-91.


Yamamoto Y, Matsuyama H, Kawauchi S, Matsumoto H, Nagao K, Ohmi C, Sakano S, Furuya T, Oga A, NaitoK. Sasaki K.
Overexpression of polo-like kinase 1(PLK1) and chromosomal instability in bladder cancer
Oncology 70:231-237, 2006


Noutomi Y, Oga A, Uchida K. Okafuji M, Ita M, Kawauchi S, Furuya T, Ueyama Y, Sasaki K.
Comparative Genomic Hybridization Reveals Genetic Progression of Oral Squamous Cell Carcinoma from Dysplasia via Two Different Tumorigenetic Pathways
Journal of Pathology 2006 210(1):67-74


Furuya T, Uchiyama T, Adachi A, Chochi Y, Oga A, Kawauchi S, Ishiglo K, Sasaki K.
Relation of DNA ploidy to genetic aberrations detected by chromosomal CGH and FISH in gastric adenocarcinomas.
Oncol Rep. 2006 Jun;15(6):1491-6.


Ohguri T, Hisaoka M, Kawauchi S, Sasaki K, Aoki T, Kanemitsu S, Matsuyama A, Korogi Y, Hashimoto H.
Cytogenetic analysis of myxoid liposarcoma and myxofibrosarcoma by array-based comparative genomic hybridization.
J Clin Pathol. 2006 59(9):978-83


Yamamoto Y, Matsuyama H, Kawauchi S, Furuya T, Liu X-P, Ikemoto K, Oga A, Naito K, Sasaki K.
Biological characteristics in bladder cancer depend on the type of genetic instability.
Clinical Cancer Research 2006 May 1;12(9):2752-8
.

Uchida K, Oga A, Okafuji M, Mihara M, Kawauchi S, Furuya T, Chochi Y, Ueyama Y, Sasaki K,
Molecular cytogenetic analysis of oral squamous cell carcinomas by comparative genomic hybridization, spectral karyotyping, and fluorescence in situhybridization.
Cancer Genetics and Cytogenetics 2006 Jun;167(2):109-16.



-2005-

Hayashi M, Kawauchi S, Ueda K, Kaneda Y, Oga A, Furuya T, Hamano K, Sasaki K.
Genomic alterations detected by comparative genomic hybridization in primary lung adenocarcinomas with special reference to the relationship with DNA ploidy.
Oncol Rep. 2005 Dec;14(6):1429-35

Kawauchi S, Sasaki K.
Comparative genomic hybridization for DNA extracted from cytological smear.
Hum Pathol. 2005 Nov;36(11):1241-2. Epub 2005 Oct 7.


Kawauchi S, Okuda S, Morioka H, Iwasaki F, Fukuma F, Chochi Y, Furuya T, Oga A, Sasaki K.

Large cell neuroendocrine carcinoma of the uterine cervix with cytogenetic analysis by comparative genomic hybridization: a case study.
Hum Pathol. 2005;36(10):1096-100.


Kawauchi S, Fukuda T, Chochi Y, Kondo T, Oga A, Sasaki K.
Reverse transcription-polymerase chain reaction in situ hybridization for SYT-SSX fusion gene transcripts in synovial sarcomas.
Int J Mol Med. 2005 Oct;16(4):763-766.


Inomata K, Oga A, Kawauchi S, Furuya T, Sasaki K.
Global genomic changes induced by two-stage carcinogen exposure are precancerous alterations in non-transformed human liver epithelial THLE-3 cells.
Int J Oncol. 2005 Oct;27(4):925-931.


Kitoh H, Ryozawa S, Harada T, Kondoh S, Furuya T, Kawauchi S, Oga A, Okita K, Sasaki K.
Comparative genomic hybridization analysis for pancreatic cancer specimens obtained by endoscopic ultrasonography-guided fine-needle aspiration.J Gastroenterol. 2005;40(5):511-7


-2004-
Nakahara Y, Shiraishi T, Okamoto H, Mineta T, Oishi T, Sasaki K, Tabuchi K.
Detrended fluctuation analysis of genome-wide copy number profiles of glioblastomas using array-based comparative genomic hybridization.Neuro-oncol. 2004 6(4):281-9.

Kawauchi S, Liu XP, Kawasaki K, Hirakawa T, Amada S, Furuya T, Oga A, Sasaki K. 
Significance of beta-catenin and pRB pathway components in malignant ovarian germ cell tumours: INK4A promoter CpG island methylation is associated with cell proliferation. J Pathol. 2004 ;204(3):268-76.
Yamamoto Y, Matsuyama H, Furuya T, Oga A, Yoshihiro S, Okuda M, Kawauchi S, Sasaki K, Naito K.
Centrosome hyperamplification predicts progression and tumor recurrence in bladder cancer.Clin Cancer Res. 2004 ;10(19):6449-55.
Ikemoto K, Furuya T, Matsuda K, Kawauchi S, Oga A, Ikeda J, Liu XP, Sasaki K.
Multicolor FISH and cytometric analyses allow classification of urothelial carcinomas into two subtypes, low- and high-grade tumors. Int J Oncol. 2004 ;25(4):893-8.
Tsujino K, Tsukahara M, Tsuneoka H, Ichihara K, Furuya T, Kawauchi S, Oga A, Sasaki K.
Clinical implication of prolonged fever in children with cat scratch disease.J Infect Chemother. 2004 ;10(4):227-33.

Liu XP, Sato T, Oga A, Ikemoto K, Kawauchi S, Ikeda E, Sasaki K.
Two subtypes of mucinous colorectal carcinoma characterized by laser scanning cytometry and comparative genomic hybridization.Int J Oncol. 2004 ;25(3):615-21.

Matsuda K, Matsuyama H, Hara T, Yoshihiro S, Oga A, Kawauchi S, Furuya T, Izumi H, Naito K, Sasaki K.
DNA sequence copy number aberrations in prostate cancers: a comparison of comparative genomic hybridization data between Japan and European countries.Cancer Genet Cytogenet. 2004 ;152(2):119-23.
Tsuneoka H, Umeda A, Tsukahara M, Sasaki K.
Evaluation of indirect fluorescence antibody assay for detection of Bartonella clarridgeiae and Seroprevalence of B. clarridgeiae among patients with suspected cat scratch disease. J Clin Microbiol. 2004 ;42(7):3346-9.

Toshimitsu H, Hashimoto K, Tangoku A, Iizuka N, Yamamoto K, Kawauchi S, Oga A, Furuya T, Oka M, Sasaki K.
Molecular signature linked to acquired resistance to cisplatin in esophageal cancer cells.1: Cancer Lett. 2004 28;211:69-78.
Hashimoto K, Mori N, Tamesa T, Okada T, Kawauchi S, Oga A, Furuya T, Tangoku A, Oka M, Sasaki KAnalysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH.1: Mod Pathol. 2004 ;17:617-22.
Furuya T, Ikemoto K, Kawauchi S, Oga A, Tsunoda S, Hirano T,SasakiK.
A novel technology allowing immunohistochemical staining of a tissue section with 50 different antibodies in a single experiment. J Histochem Cytochem. 2004;52 :205-10.


-2003-
Kawauchi S, Oga A, Sasaki K.
Comparative Genomic hybridization in cancer research. Recent Res.Devel.Human Pathol 2003 ;1259-272

Kawasaki K, Suehiro Y, Umayahara K, Morioka H, Ito T, Saito T, Tsukamoto N, Sugino N, Kato H, Sasaki K.
11q23-24 loss is associated with chromosomal instability in endometrial cancer. Int J
Mol Med 2003 ;12:727-31.
Ueno T, Tangoku A, Yoshino S, Abe T, Hayashi H, Toshimitsu H, Hashimoto K, Satoh T, Oga A, Furuya T, Oka M, Sasaki K.
Prediction of nodal metastasis by comparative genomic hybridization in biopsy specimens from patients with superficial esophageal squamous cell carcinoma. Clin Cancer Res 2003 ;9:5137-41. 

Azuno Y, Yaga K, Suehiro Y, Ariyama S, Oga A.
Inflammatory myoblastic tumor of the uterus and interleukin-6. Am J Obstet Gynecol 2003 189:890-1.
  

Arai H, Ueno T, Tangoku A, Yoshino S, Abe T, Kawauchi S, Oga A, Furuya T, Oka M, Sasaki K.
Detection of amplified oncogenes by genome DNA microarrays in human primary esophageal squamous cell carcinoma: comparison with conventional comparative genomic hybridization analysis.Cancer Genet Cytogenet 2003;146:16-21.

Takita M, Furuya T, Sugita T, Kawauchi S, Oga A, Hirano T, Tsunoda S, Sasaki K.
An analysis of changes in the expression of cyclins A and B1 by the cell array system during the cell cycle: Comparison between cell synchronization methods. Cytometry 2003;55A:24-9.
Numa F, Umayahara K, Ogata H, Nawata S, Sakaguchi Y, Emoto T, Kawasaki K, Hirakawa H, Sase M, Oga A, Kato H.
De novo uterine sarcoma with good response to neo-adjuvant chemotherapy. Int J Gynecol Cancer 2003;13:364-7.

Goto Y, Kawauchi S, Ihara K, Ikemoto K, Ohi R, Kawai S, Sasaki K.
The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27(Kip1) and cyclin E. Cancer Sci 2003;94:412-7.

Sasaki K, Kawauchi S.
Molecular cytogenetic analysis of solid tumors. J Orthop Sci 2003;8:457-9.
Sasaki K.
Molecular cytogenetic analysis of carcinomas of the digestive organs and its clinical application. Intern Med 2003;42:292-4.

Kawauchi S, Hayatsu Y, Takahashi M, Furuya T, Oga A, Niwa S, Sasaki K.
Spindle-cell ameloblastic carcinoma: A case report with immunohistochemical, ultrastructural, and comparative genomic hybridization analyses. Oncol Rep 2003;10:31-4.


-2002-

Umayahara K, Numa F, Suehiro Y, Sakata A, Nawata S, Ogata H, Suminami
Y, Sakamoto M, Sasaki K, Kato H.

Comparative genomic hybridization detects genetic alterations during
early stages of cervical cancer progression.
Genes Chromosomes Cancer. 2002 Jan;33(1):98-102.

Furuya T, Takita M, Tsunoda S, Kawauchi S, Hirano T, Oga A, Sasaki K.
Cell array coupled with laser scanning cytometry allows easy analysis of changes in cyclin expression during the cell cycle. An application of cell array system. Methods Cell Sci 2002;24:41-7.
Umayahara K, Numa F, Inokuma A, Sueoka K, Kawasaki K, Hirakawa H, Emoto T, Sakaguchi Y, Nawata S, Ogata H, Sakamoto M, Hasumi K, Kawauchi S, Sasaki K, Kato H.
Genetic alterations related to lymph node metastasis and peritoneal dissemination in epithelial ovarian cancers. Oncol Rep 2002;9:1115-9.
Kawauchi S, Fukuma F, Morioka H, Okuda S, Sasaki K.
Malignant lymphoma arising as a primary tumor of the uterine corpus. Pathol Int
2002;52:423-4
.

Kawauchi S, Goto Y, Ihara K, Furuya T, Oga A, Tsuneyoshi M, Kawai S, Sasaki K.
Survival analysis with p27 expression and apoptosis appears to estimate the prognosis of patients with synovial sarcoma more accurately. Cancer 2002;94:2712-8.

Oga A, Kawauchi S, Izumi H, Ping LX, Furuya T, Sasaki K.
New perspectives for tumor pathology provided by comparative genomic hybridization. Int J Clin Oncol 2002;7:133-7.
Harada T, Okita K, Shiraishi K, Kusano N, Furuya T, Oga A, Kawauchi S, Kondoh S, Sasaki K.
Detection of genetic alterations in pancreatic cancers by comparative genomic hybridization coupled with tissue microdissection and degenerate oligonucleotide primed polymerase chain reaction. Oncology 2002;62:251-8.

Goto Y, Ihara K, Kawauchi S, Ohi R, Sasaki K, Kawai S.
Clinical significance of thallium-201 scintigraphy in bone and soft tissue tumors. J
Orthop Sci 2002;7:304-12.

Liu XP, Oga A, Suehiro Y, Furuya T, Kawauchi S, Sasaki K.
Inverse relationship between matrilysin expression and proliferative activity of cells in advanced gastric carcinoma.Hum Pathol. 2002;33:741-7.
Liu XP, Kawauchi S, Oga A, Tsushimi K, Tsushimi M, Furuya T, Sasaki K.
Prognostic significance of matrix metalloproteinase-7 (MMP-7) expression at the invasive front in gastric carcinoma. Jpn J Cancer Res 2002;93:291-5.
Izumi H, Hara T, Oga A, Matsuda K, Sato Y, Naito K, Sasaki K.
High telomerase activity correlates with the stabilities of genome and DNA ploidy in renal cell carcinoma. Neoplasia 2002;4:103-11.

Harada T, Okita K, Shiraishi K, Kusano N, Kondoh S, Sasaki K.
Interglandular cytogenetic heterogeneity detected by comparative genomic hybridization in pancreatic cancer. Cancer Res 2002;62:835-9.

Kusano N, Okita K, Shirahashi H, Harada T, Shiraishi K, Oga A, Kawauchi S, Furuya T, Sasaki K.
Chromosomal imbalances detected by comparative genomic hybridization are associated with outcome of patients with hepatocellular carcinoma. Cancer 2002;94:746-51.

Nitta M, Tsuiki H, Arima Y, Harada K, Nishizaki T, Sasaki K, Mimori T, Ushio Y, Saya H.
Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability. Genes Cells 2002;7:151-62.

Ueno T, Tangoku A, Yoshino S, Abe T, Toshimitsu H, Furuya T, Kawauchi S, Oga A, Oka M, Sasaki K.
Gain of 5p15 detected by comparative genomic hybridization as an independent marker of poor prognosis in patients with esophageal squamous cell carcinoma. Clin Cancer Res 2002;8:526-33.

Nishizaki T, Harada K, Kubota H, Harada K, Furuya T, Suzuki M, Sasaki K.
Chromosome instability in malignant astrocytic tumors detected by fluorescence in situ hybridization.J Neurooncol. 2002 Jan;56(2):159-65.


-2001-
Numa F, Umayahara K, Suehiro Y, Suminami Y, Oga A, Sasaki K, Kato H.
New molecular tumor markers for endometrial cancer.Hum Cell 2001;14:272-4.

Liu XP, Kawauchi S, Oga A, Suehiro Y, Tsushimi K, Tsushimi M, Sasaki K.
Combined examination of p27(Kip1), p21(Waf1/Cip1) and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma. Histopathology 2001;39:603-10.

Kubota H, Nishizaki T, Harada K, Harada K, Oga A, Ito H, Suzuki M, Sasaki K.
Identification of recurrent chromosomal rearrangements and the unique relationship between low-level amplification and translocation in glioblastoma. Genes Chromosomes Cancer 2001;31:125-33.

Takeo S, Arai H, Kusano N, Harada T, Furuya T, Kawauchi S, Oga A, Hirano T, Yoshida T, Okita K, Sasaki K.
Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis.Cancer Genet Cytogenet. 2001;15;130 :127-32.

Hashimoto Y, Oga A, Kawauchi S, Furuya T, Shimizu N, Nakano T, Imate Y, Yamashita H, Sasaki K.
Amplification of 3q26 approximately qter correlates with tumor progression in head and neck squamous cell carcinomas. Cancer Genet Cytogenet 2001;129:52-6.
Kong G, Oga A, Park CK, Kawauchi S, Furuya T, Sasaki K.
DNA sequence copy number aberrations associated with histological subtypes and DNA ploidy in gastric carcinoma. Jpn J Cancer Res 2001;92:740-7.

Liu XP, Tsushimi K, Tsushimi M, Kawauchi S, Oga A, Furuya T, Sasaki K.
Expression of p21(WAF1/CIP1) and p53 proteins in gastric carcinoma: its relationships with cell proliferation activity and prognosis. Cancer Lett 2001 20;170:183-9.
Liu XP, Tsushimi K, Tsushimi M, Oga A, Kawauchi S, Furuya T, Sasaki K.
Expression of p53 protein as a prognostic indicator of reduced survival time in diffuse-type gastric carcinoma. Pathol Int 2001;51:440-4.

Oga A, Sadamitu D, Hattori Y, Nakamura Y, Kohno M, Kawauchi S, Sasaki K.
Imported malaria in a Japanese male: an autopsy report. Pathol Int 2001;51:371-5.

Oga A, Kong G, Tae K, Lee Y, Sasaki K.
Comparative genomic hybridization analysis reveals 3q gain resulting in genetic alteration in 3q in advanced oral squamous cell carcinoma. Cancer Genet Cytogenet 2001;127:24-9.
Shimizu T, Izumi H, Oga A, Furumoto H, Murakami T, Ofuji R, Muto M, Sasaki K.
Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin. Dermatology 2001;202:203-6.
Tsushimi T, Noshima S, Oga A, Esato K, Sasaki K.
DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping. Cancer Genet Cytogenet 2001;126:34-8.

Nakamura Y, Suehiro Y, Sugino N, Sasaki K, Kato H.
A case of 46,X,der(X)(pter-->q21::p21-->pter) with gonadal dysgenesis, tall stature, and endometriosis.Fertil Steril 2001;75:1224-5.

Numa F, Umayahara K, Suehiro Y, Hirakawa H, Nawata S, Suminami Y, Oga A, Ito T, Sasaki K, Kato HSerum anti-p53 antibodies in uterine and ovarian cancer: association with DNA sequence copy number abnormalities. Tumour Biol 2001;22:162-8.
Yang ZQ, Imoto I, Pimkhaokham A, Shimada Y, Sasaki K, Oka M, Inazawa J.
A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.Jpn J Cancer Res 2001;92:423-8.
Kawauchi S, Goto Y, Liu XP, Furuya T, Oga A, Oda Y, Tsuneyoshi M, Ihara K, Sasaki K..
Low expression of p27(Kip1), a cyclin-dependent kinase inhibitor, is a marker of poor prognosis in synovial sarcoma.Cancer 2001;91:1005-12.
Harada K, Nishizaki T, Kubota H, Harada K, Suzuki M, Sasaki K.
Distinct primary central nervous system lymphoma defined by comparative genomic hybridization and laser scanning cytometry.Cancer Genet Cytogenet 2001;125:147-50.

Shiraishi K, Okita K, Kusano N, Harada T, Kondoh S, Okita S, Ryozawa S, Ohmura R, Noguchi T, Iida Y, Akiyama T, Oga A, Fukumoto Y, Furuya T, Kawauchi S, Sasaki K.
A Comparison of DNA Copy Number Changes Detected by Comparative Genomic Hybridization in Malignancies of the Liver, Biliary Tract and Pancreas Oncology 2001;60(2):151-161.
Oga A, Kong G, Ishii Y, Izumi H, Park CY, Sasaki K.
Preferential loss of 5q14-21 in intestinal-type gastric cancer with DNA aneuploidy. Cytometry 2001;46:57-62.
Nakao K, Shibusawa M, Ishihara A, Yoshizawa H, Tsunoda A, Kusano M, Kurose A, Makita T, Sasaki KGenetic changes in colorectal carcinoma tumors with liver metastases analyzed by comparative genomic hybridization and DNA ploidy. Cancer 2001;91:721-726.
Shiraishi K, Okita K, Harada T, Kusano N, Furui T, Kondoh S, Oga A, Kawauchi S, Fukumoto Y, Sasaki K.
Comparative genomic hybridization analysis of genetic aberrations associated with development and progression of biliary tract carcinomas Cancer 2001;91:570-7.


-2000-
Harada T, Shiraishi K, Kusano N, Umayahara K, Kondoh S, Okita K, Sasaki K.
Evaluation of the reliability of chromosomal imbalances detected by combined use of universal DNA amplification and comparative genomic hybridization. Jpn J Cancer Res
2000;91:1119-25.

Harada K, Nishizaki T, Maekawa K, Kubota H, Harada K, Suzuki M, Ohno T, Sasaki K, Soeda E.
A sequence-ready BAC clone contig of human chromosome 10p15 spanning the loss of heterozygosity region in glioma. Genomics 2000;67:268-72.
Oode K, Furuya T, Harada K, Kawauchi S, Yamamoto K, Hirano T, Sasaki K.
The development of a cell array and its combination with laser-scanning cytometry allows a high-throughput analysis of nuclear DNA content. Am J Pathol 2000;157: 723-8.

Suehiro Y, Umayahara K, Ogata H, Numa F, Yamashita Y, Oga A, Morioka H, Ito T, Kato H, Sasaki K.
Genetic aberrations detected by comparative genomic hybridization predict outcome in patients with endometrial carcinoma. Genes Chromosomes Cancer 2000;29:75-82.
Kawauchi S, Fukuda T, Oda Y, Saito T, Oga A, Takeshita M, Yokoyama K, Chuman H, Iwamoto Y, Sasaki K, Tsuneyoshi M.
Prognostic significance of apoptosis in synovial sarcoma: correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related proteins. Mod Pathol 2000;13:755-65.

Furuya T, Uchiyama T, Murakami T, Adachi A, Kawauchi S, Oga A, Hirano T, Sasaki K.
Relationship between chromosomal instability and intratumoral regional DNA ploidy heterogeneity in primary gastric cancers. Clin Cancer Res 2000;6:2815-20.

Hashimoto Y, Oga A, Okami K, Imate Y, Yamashita Y, Sasaki K.
Relationship between cytogenetic aberrations by CGH coupled with tissue microdissection and DNA ploidy by laser scanning cytometry in head and neck squamous
cell carcinoma.Cytometry 2000;40:161-6.

Nishizaki T, Kubota H, Harada K, Harada K, Ito H, Suzuki M, Sasaki K.
Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization. Hum Pathol 2000;31:608-14.

Okafuji M, Ita M, Oga A, Hayatsu Y, Matsuo A, Shinzato Y, Shinozaki F, Sasaki K.
The relationship of genetic aberrations detected by comparative genomic hybridization to DNA ploidy and tumor size in human oral squamous cell carcinoma. J Oral Pathol Med 2000;29:226-31.
Kawasaki K, Murakami T, Ita M, Sasaki K, Furukawa S.
KRN5500, a novel antitumor agent, induces apoptosis or cell differentiation in HL-60 cells.Cytometry 2000;39:211-6.

Tada K, Oka M, Hayashi H, Tangoku A, Oga A, Sasaki K.
Cytogenetic analysis of esophageal squamous cell carcinoma cell lines by comparative genomic hybridization: relationship of cytogenetic aberrations to in vitro cell growth. Cancer Genet Cytogenet 2000;117:108-12.

Sakumura T, Fujii Z, Umemoto S, Murakami T, Kawata Y, Fujii K, Minami M, Sasaki K, Matsuzaki M.
Dilazep, a nucleoside transporter inhibitor, modulates cell cycle progression and DNA synthesis in rat mesangial cells in vitro.Cell Prolif 2000;33:19-28.
 

Kobayashi Y, Esato K, Noshima S, Oga A, Sasaki K.
Detection of 20q13 gain by dual-color FISH in breast cancers. Anticancer Res 2000;20:531-5.

Tada K, Oka M, Tangoku A, Hayashi H, Oga A, Sasaki K.
Gains of 8q23-qter in esophageal squamous cell carcinoma associated with lymph node metastasis. Cancer 2000;88:268-73.
Oga A, Ohzono Y, Yoshizawa H, Sasaki K.
A Simple Method for Cell Isolation from Paraffin-Embedded Tissue Specimens for Flow Cytometric DNA Analysis. The Bulletin of The Yamaguchi MEdical School 2000;46:99-104
 


-1999-
Miyazaki M, Furuya T, Shiraki A, Sato T, Oga A, Sasaki K.
The relationship of DNA ploidy to chromosomal instability in primary human colorectal cancers. Cancer Res 1999;59:5283-5.

Sato T, Oga A, Ikeda E, Todoroki T, Furuya T, Sasaki K.
Cytogenetic aberrations detected by flow cytometry and fluorescence in situ hybridization in colorectal cancers: two cytogenetic pathways in colorectal carcinogenesis. Oncology 1999;57:63-69.

Shiraishi K, Kusano N, Okita S, Oga A, Okita K, Sasaki K.
Genetic aberrations detected by comparative genomic hybridization in biliary tract cancers. Oncology 1999;57:42-49.

Kusano N, Shiraishi K, Kubo K, Oga A, Okita K, Sasaki K.
Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: Their relationship to clinicopathological features. Hepatology 1999;29:1858-1862.

Okafuji M, Ita M, Hayatsu Y, Shinozaki F, Oga A, Sasaki K.
Identification of genetic aberrations in cell lines from oral squamous cell carcinomas by comparative genomic hybridization. J Oral Pathol Med 1999;28:241-245.

Ozaki S, Nishizaki T, Ito H, Sasaki K.
Comparative genomic hybridization analysis of genetic alterations associated with malignant progression of meningioma.J Neurooncol 1999;41:167-174.
Harada K, Nishizaki T, Ozaki S, Kubota H, Harada K, Okamura T, Ito H, Sasaki K.
Cytogenetic alterations in pituitary adenomas detected by comparative genomic hybridization. Cancer Genet Cytogenet 1999;12:38-41.
Nishizaki T, Harada K, Kubota H, Harada K, Ozaki S, Ito H, Sasaki K.
Genetic alterations in pediatric medulloblastomas detected by comparative genomic hybridization. Pediatr Neurosurg 1999;31:27-32.
Ishihara A, Nakao K, Yoshizawa H, Murakami M, Kusano M, Sasaki K.
Comparative genomic hybridization analysis of chromosomal aberration associated with hepatitis C virus-related hepatocellular carcinoma. Hepatol Res 1999;32-42:15
.
Satoh T, Yamamoto K, Miura F-K, Sasaki K, Ishidate M Jr.
Application of laser scanning cytometry to the analysis of chromosomal aberrations induced by benzo[a]pyrene in CHO-WBLT cells. Cytometry 1999;35:363-368.

 
-1998-
Harada K, Nishizaki T, Ozaki S, Kubota H, Ito H, Sasaki K.
Intratumoral cytogenetic heterogeneity detected by comparative genomic hybridization and laser scanning cytometry in human gliomas. Cancer Res 1998;58:4694-700.

Kato A, Kubo K, Kurokawa F, Okita K, Oga A, Murakami T.
Numerical aberrations of chromosomes 16, 17, and 18 in hepatocellular carcinoma: a FISH and FCM analysis of 20 cases.Dig Dis Sci 1998 ;43:1-7.

Nishizaki T, Ozaki S, Harada K, Ito H, Arai H, Beppu T, Sasaki K.
Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization. Genes Chromosomes Cancer 1998;21:340-346.
Darzynkiewicz Z, Bender E, Traganos F, Murakami T.
Critical aspects in the analysis of apoptosis and necrosis. Hum Cell 1998;11:3-12.

Nakao K, Shibusawa M, Tsunoda A, Yoshizawa H, Murakami M, Kusano M, Uesugi N, Sasaki K.
Genetic changes in primary colorectal cancer by comparative genomic hybridization. Surg Today 1998;28:567-569.
Oga A, Kadowaki T, Hamanaka S, Sasaki K.
Dystrophic calcinosis cutis in the skin below the mandible of a violinist. Br J Dermatol 1998;139:940-941.

Kobayashi J, Sekimoto A, Uchida H, Wada T, Sasaki K, Sasada H, Umezu M, Sato E.
Rapid detection of male-specific DNA sequence in bovine embryos using fluorescence in situ hybridization, Mol Reproduct Develop 1998;51:390-394.

 
-1997-
Tsuji T, Mimura Y, Kawasaki A, Okafuji M, Kamada T, Murakami T, Sasaki K, Shinozaki F.
Increased polysomy 3 and 17 detected by fluorescence in situ hybridization (FISH) in oral squamous cell carcinoma. Oncol Rep 1997;4:277-280.

Li X, Tsuji T, Wen S, Mimura Y, Sasaki K, Shinozaki F.
Detection of numeric abnormalities of chromosome 17 and p53 deletions by fluorescence in situ hybridization in pleomorphic adenomas and carcinomas in pleomorphic adenoma.
Cancer 1997;79:2314-2319.

Furuya T, Kamada T, Murakami T, Kurose A, Sasaki K.
Laser scanning cytometry allows detection of cell death with morphological features of apoptosis in cells stained with PI. Cytometry 1997;29:173-7.
Kamada T, Sasaki K, Tsuji T, Todoroki T, Takahashi M, Kurose
A. Sample preparation from paraffin-embedded tissue specimens for laser scanning cytometric DNA analysis. Cytometry 1997;27:290-294
Kamentsky LA, Kamentsky LD, Fletcher JA, Kurose A, Sasaki K.
Methods for automatic multiparameter analysis of fluorescence in situ hybridized specimens with a laser scanning cytometer.
Cytometry 1997;27:117-125.
Sato T, Abe K, Kurose A, Uesugi N, Todoroki T, Sasaki K.
Amplification of the c-erbB-2 gene detected by FISH in gastric cancers. Pathol Int 1997;47:179-182.
Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F.
Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis). Cytometry 1997;27:1-20.

Kawasaki M, Sasaki K, Satoh T, Kurose A, Kamada T, Furuya T, Murakami T, Todoroki T.
Laser scanning cytometryLSCallows detailed analysis of the cell cycle in PI stained human fibroblasts (TIG-7) Cell Prolif 1997;30:139-147.
Shii N, Ariyoshi A, Kinjo M, Sasaki K.
Detection of numerical chromosomal aberrations in bladder carcinomas by fluorescence in situ hybridization. J. Urol Pathol 1997;7:21-32.
  


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