1. Nawata T, Honda T, Sakamoto A, Uchinoumi H, Suetomi T, Nakamura Y, Tsuji S, Sakai H, Kobayashi S, Yamamoto T, Asagiri M, Sano M, Yano M.
    Role of type 2 ryanodine receptor stabilisation in autoimmune cell modulation.
    Adv Rheumatol. in press.
  2. Yasumizu Y, Hagiwara M, Umezu Y, Fuji H, Iwaisako K, Asagiri M, Uemoto S, Nakamura Y, Thul S, Ueyama A, Yokoi K, Tanemura A, Nose Y, Saito T, Wada H, Kakuda M, Kohara M, Nojima S, Morii E, Doki Y, Sakaguchi S, Ohkura N.
    Neural-net-based cell deconvolution from DNA methylation reveals tumor microenvironment associated with cancer prognosis.
    NAR Cancer. 2024 May 15;6(2):zcae022. doi: 10.1093/narcan/zcae022.
  3. Hitaka Y, Isoyama N, Tsuji S, Honda T, Nakayama Y, Yamaguchi M, Nakamura K, Hirata H, Shiraishi K, Asagiri M.
    Renoprotective effects of laxative linaclotide: Inhibition of acute kidney injury and fibrosis in a rat model of renal ischemia-reperfusion.
    Biochem Biophys Res Commun. 2024 May 21;709:149709. doi: 10.1016/j.bbrc.2024.149709.
  4. Nawata T, Honda T, Sakai H, Tsuji S, Otsuka M, Uchinoumi H, Kobayashi S, Yamamoto T, Asagiri M, Yano M.
    Dantrolene, a ryanodine receptor stabilizer, is a candidate immunomodulator for treating rheumatic disease.
    Scand J Rheumatol. 2024 May;53(3):217-219. doi: 10.1080/03009742.2023.2297519.
  5. Sawai Y, Suzuki Y, Asagiri M, Hida S, Kondo R, Zamponi GW, Giles WR, Imaizumi Y, Yamamura H.
    Caveolin-1 forms a complex with P2X7 receptor and tunes P2X7-mediated ATP signaling in mouse bone marrow-derived macrophages.
    Am J Physiol Cell Physiol. 2024 Jan 1;326(1):C125-C142. doi: 10.1152/ajpcell.00303.2023.
  6. Nawata T, Sakai H, Honda T, Otsuka M, Fujita H, Uchinoumi H, Kobayashi S, Yamamoto T, Asagiri M, Yano M.
    Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.
    Biochem Biophys Res Commun. 2022 Oct 8;624:141-145. doi: 10.1016/j.bbrc.2022.07.111.
  7. Honda T, Nishio Y, Sakai H, Asagiri M, Yoshimura K, Inui M, Kuramasu A.
    Calcium/calmodulin-dependent regulation of Rac GTPases and Akt in histamine-induced chemotaxis of mast cells.
    Cell Signal. 2021 Mar 6;83:109973. doi: 10.1016/j.cellsig.2021.109973.
  8. Fukuyama K, Asagiri M, Sugimoto M, Tsushima H, Seo S, Taura K, Uemoto S, Iwaisako K.
    Gene expression profiles of liver cancer cell lines reveal two hepatocyte-like and fibroblast-like clusters.
    PLoS One. 2021 Feb 4;16(2):e0245939. doi: 10.1371/journal.pone.0245939.
  9. Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
    Cell Cycle Perturbation Induces Collagen Production in Fibroblasts.
    Int Heart J. 2019 Jul 27;60(4):958-963. doi: 10.1536/ihj.18-710.
  10. Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
    Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.
    Nat Commun. 2019 Jun 27;10(1):2824. doi: 10.1038/s41467-019-10859-w.
  11. Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M.
    Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation.
    Biochem Biophys Res Commun. 2018 Sep 5;503(2):544-549. doi: 10.1016/j.bbrc.2018.05.153.
  12. Yamamoto G, Taura K, Iwaisako K, Asagiri M, Ito S, Koyama Y, Tanabe K, Iguchi K, Satoh M, Nishio T, Okuda Y, Ikeno Y, Yoshino K, Seo S, Hatano E, Uemoto S.
    Pancreatic Stellate Cells Have Distinct Characteristics From Hepatic Stellate Cells and Are Not the Unique Origin of Collagen-Producing Cells in the Pancreas.
    Pancreas. 2017 Oct;46(9):1141-1151. doi: 10.1097/MPA.0000000000000901.
  13. Sarashina-Kida H, Negishi H, Nishio J, Suda W, Nakajima Y, Yasui-Kato M, Iwaisako K, Kang S, Endo N, Yanai H, Asagiri M, Kida H, Hattori M, Kumanogoh A, Taniguchi T.
    Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.
    Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10178-10183. doi: 10.1073/pnas.1712837114.
  14. Nishio T, Taura K, Iwaisako K, Koyama Y, Tanabe K, Yamamoto G, Okuda Y, Ikeno Y, Yoshino K, Kasai Y, Okuno M, Seo S, Sakurai T, Asagiri M, Hatano E, Uemoto S.
    Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis.
    J Gastroenterol. 2017 Aug;52(8):965-976. doi: 10.1007/s00535-016-1304-z.
  15. Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M.
    Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K.
    Sci Rep. 2017 Mar 16;7:41710. doi: 10.1038/srep41710.
  16. Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
    HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
    Nat Commun. 2016 May 18;7:11635. doi: 10.1038/ncomms11635.
  17. Zhao C, Ichimura A, Qian N, Iida T, Yamazaki D, Noma N, Asagiri M, Yamamoto K, Komazaki S, Sato C, Aoyama F, Sawaguchi A, Kakizawa S, Nishi M, Takeshima H.
    Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.
    Sci Signal. 2016 May 17;9(428):ra49. doi: 10.1126/scisignal.aad9055.
  18. Fujita T, Soontrapa K, Ito Y, Iwaisako K, Moniaga CS, Asagiri M, Majima M, Narumiya S.
    Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis.
    Hepatology. 2016 Apr;63(4):1325-39. doi: 10.1002/hep.28112.
  19. Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A.
    B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel.
    Blood. 2016 Mar 10;127(10):1276-86. doi: 10.1182/blood-2014-10-606988.
  20. Ochiya T, Takenaga K, Asagiri M, Nakano K, Satoh H, Watanabe T, Imajoh-Ohmi S, Endo H.
    Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction.
    Mol Ther Methods Clin Dev. 2015 Apr 1;2:15008. doi: 10.1038/mtm.2015.8.
  21. Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K.
    Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells.
    Int Arch Allergy Immunol. 2015;166(2):84-90. doi: 10.1159/000371419.
  22. Tanabe K, Taura K, Koyama Y, Yamamoto G, Nishio T, Okuda Y, Nakamura K, Toriguchi K, Takemoto K, Yamanaka K, Iwaisako K, Seo S, Asagiri M, Hatano E, Uemoto S.
    Migration of splenic lymphocytes promotes liver fibrosis through modification of T helper cytokine balance in mice.
    J Gastroenterol. 2015 Oct;50(10):1054-68. doi: 10.1007/s00535-015-1054-3.
  23. Iwaisako K, Taura K, Koyama Y, Takemoto K, Asagiri M.
    Strategies to Detect Hepatic Myofibroblasts in Liver Cirrhosis of Different Etiologies.
    Curr Pathobiol Rep. 2014;2(4):209-215. doi: 10.1007/s40139-014-0057-8.
  24. Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M.
    Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure.
    FEBS Open Bio. 2014 Sep 6;4:777-87. doi: 10.1016/j.fob.2014.08.007.
  25. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA, Hofmann AF, Iida T, Glass CK, Brenner DA, Kisseleva T.
    Origin of myofibroblasts in the fibrotic liver in mice.
    Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3297-305. doi: 10.1073/pnas.1400062111.
  26. Saito S, Hata K, Iwaisako K, Yanagida A, Takeiri M, Tanaka H, Kageyama S, Hirao H, Ikeda K, Asagiri M, Uemoto S.
    Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis.
    Hepatol Res. 2014 Apr;44(4):460-73. doi: 10.1111/hepr.12140.
  27. Soeno Y, Fujita K, Kudo T, Asagiri M, Kakuta S, Taya Y, Shimazu Y, Sato K, Tanaka-Fujita R, Kubo S, Iwakura Y, Nakamura Y, Mori S, Aoba T.
    Generation of a mouse model with down-regulated U50 snoRNA (SNORD50) expression and its organ-specific phenotypic modulation.
    PLoS One. 2013 Aug 26;8(8):e72105. doi: 10.1371/journal.pone.0072105.
  28. Shih VF, Davis-Turak J, Macal M, Huang JQ, Ponomarenko J, Kearns JD, Yu T, Fagerlund R, Asagiri M, Zuniga EI, Hoffmann A.
    Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways.
    Nat Immunol. 2012 Dec;13(12):1162-70. doi: 10.1038/ni.2446.
  29. Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G.
    The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements.
    Cell Rep. 2012 Oct 25;2(4):824-39. doi: 10.1016/j.celrep.2012.08.042.
  30. Kanemaru K, Nakamura Y, Sato K, Kojima R, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Kabashima K, Nakahigashi K, Asagiri M, Jamora C, Yamaguchi H, Fukami K.
    Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice.
    Nat Commun. 2012 Jul 17;3:963. doi: 10.1038/ncomms1960.
  31. Ho JQ, Asagiri M, Hoffmann A, Ghosh G.
    NF-κB potentiates caspase independent hydrogen peroxide induced cell death.
    PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
  32. Okabayashi T, Nakanishi K, Tsuchihara T, Arino H, Yoshihara Y, Tominaga S, Uenoyama M, Suzuki S, Asagiri M, Nemoto K.
    Axonal-transport-mediated gene transduction in the interior of rat bone.
    PLoS One. 2010 Sep 28;5(9):e13034. doi: 10.1371/journal.pone.0013034.
  33. von Vietinghoff S, Asagiri M, Azar D, Hoffmann A, Ley K.
    Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-κB-deficient mice.
    J Immunol. 2010 Jul 1;185(1):670-8. doi: 10.4049/jimmunol.1000339.
  34. Takeda N, O’Dea EL, Doedens A, Kim JW, Weidemann A, Stockmann C, Asagiri M, Simon MC, Hoffmann A, Johnson RS.
    Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis.
    Genes Dev. 2010 Mar 1;24(5):491-501. doi: 10.1101/gad.1881410.
  35. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H.
    Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
    Science. 2008 Feb 1;319(5863):624-7. doi: 10.1126/science.1150110.
  36. Asagiri M, Takayanagi H.
    The molecular understanding of osteoclast differentiation.
    Bone. 2007 Feb;40(2):251-64. doi: 10.1016/j.bone.2006.09.023.
  37. Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, Morita I, Wagner EF, Mak TW, Serfling E, Takayanagi H.
    Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.
    J Exp Med. 2005 Nov 7;202(9):1261-9. doi: 10.1084/jem.20051150.
  38. Kim Y, Sato K, Asagiri M, Morita I, Soma K, Takayanagi H.
    Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis.
    J Biol Chem. 2005 Sep 23;280(38):32905-13. doi: 10.1074/jbc.M505820200.
  39. Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima K, Takayanagi H.
    NFAT and Osterix cooperatively regulate bone formation.
    Nat Med. 2005 Aug;11(8):880-5. doi: 10.1038/nm1270.
  40. Takatsuna H, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K.
    Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1.
    J Bone Miner Res. 2005 Apr;20(4):653-62. doi: 10.1359/JBMR.041213.
  41. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T.
    IRF-7 is the master regulator of type-I interferon-dependent immune responses.
    Nature. 2005 Apr 7;434(7034):772-7. doi: 10.1038/nature03464.
  42. Tashiro E, Minato Y, Maruki H, Asagiri M, Imoto M.
    Regulation of FGF receptor-2 expression by transcription factor E2F-1.
    Oncogene. 2003 Aug 28;22(36):5630-5. doi: 10.1038/sj.onc.1206636.
  43. Sakaguchi S, Negishi H, Asagiri M, Nakajima C, Mizutani T, Takaoka A, Honda K, Taniguchi T.
    Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock.
    Biochem Biophys Res Commun. 2003 Jul 11;306(4):860-6. doi: 10.1016/s0006-291x(03)01049-0.
  44. Hata N, Sato M, Takaoka A, Asagiri M, Tanaka N, Taniguchi T.
    Constitutive IFN-α/β signal for efficient IFN-α/β gene induction by virus.
    Biochem Biophys Res Commun. 2001 Jul 13;285(2):518-25. doi: 10.1006/bbrc.2001.5159.
  45. Nakaya T, Sato M, Hata N, Asagiri M, Suemori H, Noguchi S, Tanaka N, Taniguchi T.
    Gene induction pathways mediated by distinct IRFs during viral infection.
    Biochem Biophys Res Commun. 2001 May 25;283(5):1150-6. doi: 10.1006/bbrc.2001.4913.
  46. Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, Nakaya T, Katsuki M, Noguchi S, Tanaka N, Taniguchi T.
    Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction.
    Immunity. 2000 Oct;13(4):539-48. doi: 10.1016/s1074-7613(00)00053-4.
  47. Sato M, Hata N, Asagiri M, Nakaya T, Taniguchi T, Tanaka N.
    Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7.
    FEBS Lett. 1998 Dec 11;441(1):106-10. doi: 10.1016/s0014-5793(98)01514-2.