The aim of our research is to clarify molecular mechanisms involved in functional regulation of human proteins (proteome) systematically. We are making study on the human proteome expression and function in physiological state and disease state by two-dimensional gel electrophoresis and mass spectrometry by combination with protein chip technology. Our data are integrated to construct the international database used for understanding of molecular basis of life system and for developing new diagnostics and therapeutics of hepatocellular carcinoma with hepatitis C virus infection, T lymphoblastic leukemia, malignant mesothelioma, gastric cancer with H. pyroli infection. To promote international collaborations for studies on human proteome we founded the Human Proteome Organisation (HUPO) and Japan HUPO where we are developing the standards for proteome research and platform of international proteome database. We are also making guidelines for international education and training course for graduate students under the name of HUPO. Furthermore, we are investigating the protein-protein interactions leading to heat stress-induced apoptosis of leukemia cells and the functional relationship between apolipoprotein and cause of diseases such as neuronal disorder and cancer.

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Human Disease Proteome Profiling