器官解剖学 Department of Organ Anatomy & NANOMEDICINE
中村教泰
シリカナノ粒子の高機能セラノスティクス (第27章)
ドラッグデリバリーシステム-バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発-
2018
Doura T, Tamanoi F, Nakamura M:
Miniaturization of thiol-organosilica nanoparticles induced by an anionic
surfactant.
J. Colloid Interface Sci.,.2018, 526, 51-62.
Nakamura M, Hayashi K, Kubo H, Harada M, Izumi K, Tsuruo Y, Yogo T:
Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation:
An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles.
Sci. Rep., 7(1), 3953, 2017.( DOI: 10.1038/s41598-017-04043-7., PubMed: 28638087 )
Nakamura M, Hayashi K, Kubo H, Kanadani T, Harada M, Yogo T:
Relaxometric property of organosilica nanoparticles internally functionalized with iron oxide and fluorescent dye for multimodal imaging.
J Colloid Interface Sci., 492, 127-135, 2017.( DOI: 10.1016/j.jcis.2017.01.004., PubMed: 28086116 )
中村教泰
有機シリカナノ粒子の作製と応用
顕微鏡 Vol. 52, No. , 2017, pp170-173
Hayashi K, Maruhashi T, Nakamura M, Sakamoto W, Yogo T:
One-pot synthesis of dual stimulus-responsive degradable hollow hybrid
nanoparticles for image-guided trimodality therapy.
Advanced Functional Materials, 26(47), 8613-8622, 2016.( DOI: 10.1002/adfm.201603394)
Nakamura M, Hayashi K, Nakano M, Kanadani T, Miyamoto K, Kori T, Horikawa
K:
Identification of Polyethylene Glycol-Resistant Macrophages on Stealth
Imaging In Vitro Using Fluorescent Organosilica Nanoparticles.
ACS Nano, 9(2), 1058-1071, 2015. ( DOI: 10.1021/nn502319r, PubMed: 25629765 )
Hayashi K, Nakamura M, Miki H, Ozaki S, Abe M, Matsumoto T, Sakamoto W, Yogo T, Ishimura K:
Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a
Combination of Magnetic Hyperthermia and Remote-Control Drug Release.
Theranostics, 4(8), 834-844, 2014.( DOI: 10.7150/thno.9199., PubMed: 24955144 )
Hayashi K, Nakamura M, Miki H, Ozaki S, Abe M, Matsumoto T, Kori T, Ishimura
K:
Photostable Iodinated Silica/Porphyrin Hybrid Nanoparticles with Heavy-Atom
Effect for Wide-Field Photodynamic/Photothermal Therapy Using Single Light
Source.
Advanced Functional Materials, 24(4), 503-513, 2014.( DOI: 10.1002/adfm.201301771. )
Hayashi K, Nakamura M, Sakamoto W, Yogo T, Miki H, Ozaki S, Abe M, Matsumoto
T, Ishimura K: Superparamagnetic Nanoparticle Clusters for Cancer Theranostics
Combining Magnetic Resonance Imaging and Hyperthermia Treatment.
Theranostics, 3(6), 366-376, 2013.( DOI: 10.7150/thno.5860., PubMed: 23781284 )
Hayashi K, Nakamura M, Miki H, Ozaki S, Abe M, Matsumoto T, Ishimura K:
Gold Nanoparticle Cluster/Plasmon-Enhanced Fluorescent Silica Core-Shell
Nanoparticles for X-Ray Computed Tomography/Fluorescence Dual-Mode Imaging
of Tumors.
Chemical Communications, 49, 5334-5336, 2013.( DOI: 10.1039/c3cc41876f., PubMed: 23648868
Hayashi K, Nakamura M, Ishimura K:
Near-Infrared Fluorescent Silica-Coated Gold Nanoparticle Clusters for
X-Ray Computed Tomography/Optical Dual Modal Imaging of the Lymphatic System.
Advanced Healthcare Materials, 2(5), 756-763, 2013.( DOI: 10.1002/adhm.201200238., PubMed: 23184510 )
Nakamura M, Miyamoto K, Hayashi K, Awaad A, Ochiai M, Ishimura K:
Time-Lapse Fluorescence Imaging and Quantitative Single Cell and Endosomal Analysis of Peritoneal Macrophages Using Fluorescent Organosilica Nanoparticles.
Nanomedicine : Nanotechnology, Biology, and Medicine, 9(2), 274-283, 2013.( DOI: 10.1016/j.nano.2012.05.018., PubMed: 22698808 )
Nakamura M, Awaad A, Hayashi K, Ochiai K, Ishimura K:
Thiol-organosilica Particles Internally Functionalized with Propidium Iodide
as a Multicolor Fluorescence and X-Ray Computed Tomography Probe and Application
for Non-Invasive Functional Gastrointestinal Tract Imaging.
Chemistry of Materials, 24(19), 3772-3779, 2012.( DOI: 10.1021/cm3023677 )
Awaad A, Nakamura M, Ishimura K:
Imaging of size dependent uptake and identification of novel pathways in
mouse Peyer's patches using fluorescent organosilica particles.
Nanomedicine : Nanotechnology, Biology, and Medicine, 8, 627-636, 2012.( DOI: 10.1016/j.nano.2011.08.009, PubMed: 21889475 )
Hayashi K, Nakamura M, Sakamoto W, Yogo T, Ishimura K:
Synthesis and 3D Hierarchical Organization of 2D Structured Iron Oxide
Based on Enzymatic Structure, Activity and Thermostability.
Materials Research Bulletin, 47(12), 3959-3964, 2012.( DOI: 10.1016/j.materresbull.2012.08.011
Awaad A, Nakamura M, Ishimura K:
Histochemical and biochemical analysis of the size-dependent nanoimmunoresponse
in mouse Peyer's patches using fluorescent organosilica particles.
International Journal of Nanomedicine, 7, 1423-1439, 2012.( DOI: 10.2147/IJN.S28675, PubMed: 22619503 )
Hayashi K, Nakamura M, Miki H, Ozaki S, Abe M, Matsumoto T, Ishimura K:
Near-Infrared Fluorescent Silica/Porphyrin Hybrid Nanorings for In Vivo
Cancer Imaging.
Advanced Functional Materials, 22(17), 3539-3546, 2012.( DOI: 10.1002/adfm.201200219 )
Hayashi K, Nakamura M, Ishimura K:
Silica-Porphyrin Hybrid Nanotubes for in vivo Cell Tracking by Near-Infrared
Fluorescence Imaging.
Chemical Communications, 48(32), 3830--3832, 2012.( DOI: 10.1039/c2cc17444h, PubMed: 22437325 )
Nakamura, M. :
Biomedical applications of organosilica nanoparticles toward theranostics,
Nanotechnology Reviews, 1(6), 469?491, 2012
Hayashi K, Nakamura M, Makita Y, Fujiwara R, Kori T, Ishimura K:
Synthesis and Photocatalytic Activity of Sea Urchin-Shaped Rutile TiO2
Nanocrystals.
Materials Letters, 65(19-20), 3037-3040, 2011.( DOI: 10.1016/j.matlet.2011.06.044 )
Hayashi K, Nakamura M, Sakamoto W, Yogo T, Kori T, Ishimura K:
Formation of TiO2 Nanostructures by Enzyme-Mediated Self-Assembly for the
Destruction of Macrophages.
Chemistry of Materials, 23(14), 3341-3347, 2011.( DOI: 10.1021/cm200826c )
Hayashi K, Nakamura M, Ishimura K:
In Situ Synthesis and Photoresponsive Rupture of Organosilica Nanocapsules.
Chemical Communications, 47(5), 1518-1520, 2011.( DOI: 10.1039/c0cc03452e, PubMed: 21103535 )
Nakamura M, Ozaki S, Abe M, Matsumoto T, Ishimura K:
One-pot synthesis and characterization of dual fluorescent thiol-organosilica nanoparticles as non-photoblinking quantum dots and their applications for biological imaging.
Journal of Materials Chemistry, 21, 4689-4695, 2011.( DOI: 10.1039/C0JM04259E )
Nakamura M, Ishimura K:
Rapid Size Evaluation of Nanoparticles Using Flow Cytometry.
Advanced Science Letters, 3(2), 130-137, 2010. DOI: 10.1166/asl.2010.1096 )
Nakamura M, Ozaki S, Abe M, Doi H, Matsumoto T, Ishimura K:
Size-controlled synthesis, surface functionalization, and biological applications of thiol-organosilica particles. Colloids and Surfaces B:Biointerfaces, 79(1), 19-26, 2010.( DOI: 10.1016/j.colsurfb.2010.03.008, PubMed: 20417071 )
Miyoshi H, Imura H, Nakamura M:
Control of emission peaks of X-ray phosphor using dye-silica nanoparticles.
Journal of Luminescence, 130(3), 404-410, 2010.( DOI: 10.1016/j.jlumin.2009.10.004 )
中村 教泰, 石村 和敬 :
新規な有機シリカナノ粒子の作製と光線力学的治療への応用.
日本レーザー医学会誌, 30巻, 4号, 394-398頁, 2010年.
Nakamura M:
Approaches to Biofunctionalization of Spherical Silica Nanomaterials.
Wiley-VCH Verlag GmbH & Co. KGaA, 2009.
Nakamura M, Ishimura K:
Size-controlled, One-pot Synthesis, Characterization, and Biological Applications
of Epoxy-Organosilica Particles Possessing Positive Zeta Potential as Prepared.
Langmuir.
Langmuir, 24(21), 12228-12234, 2008.( DOI: 10.1021/la801950q, PubMed: 18823130 )
Nakamura M, Ishimura K:
One-pot synthesis and characterization of three kinds of thiol-organosilica nanoparticles.
Langmuir, 24(9), 5099-5108, 2008.( DOI: 10.1021/la703395w, PubMed: 18366224 )
Nakamura M, Ishimura K:
Synthesis and characterization of organosilica nanoparticles prepared from
3-mercaptopropyltrimethoxysilane as the single silica source.
The Journal of Physical Chemistry C, 111(51), 18892-18898, 2007.( DOI: 10.1021/jp075798o )
Nakamura M, Shono M, Ishimura K:
Synthesis, Characterization, and Biological Applications of Multifluorescent Silica Nanoparticles.
Analytical Chemistry, 79(17), 6507-6514, 2007.( DOI: 10.1021/ac070394d, PubMed: 17658763 )
Liu Y, Miyoshi H, Nakamura M:
Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis by targeted functional nanoparticles.
International Journal of Cancer, 120(12), 2527-2537, 2007.( DOI: 10.1002/ijc.22709, PubMed: 17390371 )
Liu Y, Miyoshi H, Nakamura M:
Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: Preparation and fluorescein isothiocyanate (FITC) release kinetics.
Colloids and Surfaces B:Biointerfaces, 58(2), 180-187, 2007.( DOI: 10.1016/j.colsurfb.2007.03.005, PubMed: 17420116 )