山口大学 大学院医学系研究科 器官病態外科学講座 (第一外科)

医療関係者の方へ 再生医療の業績

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業績一覧

2024

  1. Ueno K, Kurazumi H, Suzuki R, Yanagihara M, Mizoguchi T, Harada T, Morikage N, Hamano K.  miR-709 exerts an angiogenic effect through a FGF2 upregulation induced by a GSK3B downregulation Scientific Reports 14:11372 2024

2023

  1. Yoshimine S, Tanaka T, Murakami J, Yamamoto N, Ueno K, Kurazumi H, Ikeda E, Hamano K.  Postoperative changes in bronchial stump following covering with free fat tissue in a rat model European Journal of Cardio-Thoracic Surgery 63:ezad154 2023
  2. Yamamoto N, Ueno K, Yanagihara M, Kurazumi H, Tanaka Y, Oga A, Shimokawa M, Harada E, Tanaka T, Hamano K Allogenic multilayered fibroblast sheets promote anastomotic site healing in a rat model of esophageal reconstruction American Journal of Translational Research 15:3217-3228 2023
  3. Yanagihara M, Matsuno Y, Ueno K, Kurazumi H, Suzuki R, Tanaka T, Hamano K.  Fibroblasts are the most suitable cell source for regenerative medicine due to their high intracellular fibroblast growth factor 2 content Biochemistry and Biophysics Reports 35:101510 2023

2022

  1. Ike S, Ueno K, Yanagihara M, Mizoguchi T, Harada T, Suehiro K, Kurazumi H, Suzuki R, Kondo T, Murata T, Shirasawa B, Morikage N, Hamano K. Cryopreserved allogenic fibroblast sheets: development of a promising treatment for refractory skin ulcers American Journal of Translational Research  14:3879-3892 2022
  2. Matsuno Y, Yanagihara M, Ueno K, Saito T, Kurazumi H, Suzuki R, Katsura S, Oga A, Hamano K Dry preserved multilayered fibroblast cell sheets are a new manageable tool for regenerative medicine to promote wound healing Scientific Reports 12:12519 2022

2021

  1. Iwamoto K, Saito T, Takemoto Y, Ueno K, Yanagihara M, Furuya-Kondo T, Kurazumi H, Tanaka Y, Taura Y, Harada E, Hamano K.  Autologous Transplantation of Multilayered Fibroblast Sheets Prevents Postoperative Pancreatic Fistula by Regulating Fibrosis and Angiogenesis American Journal of Translational Research 13:1257-1268. 2021
  2. Yoshimine S, Ueno K, Murakami J, Saito T, Suzuki R, Asai Y, Ikeda E, Tanaka T, Hamano K
  3. Autologous multilayered fibroblast sheets can reinforce bronchial stump in a rat model Seminars in Thoracic and Cardiovascular Surgery Spring;34(1):349-358.
  4. Mizoguchi T, Suehiro K, Ueno K, Ike S, Nagase T, Samura M, Harada T, Kurazumi H, Suzuki R, Harada K, Takami T, Morikage N, Hamano K.  A Pilot Study Using Cell-Mixed Sheets of Autologous Fibroblast Cells and Peripheral Blood Mononuclear Cells to Treat Refractory Cutaneous Ulcers American Journal of Translational Research 13:9495-950 2021
  5. Ueno K, Ike S, Yamamoto N, Matsuno Y, Kurazumi H, Suzuki R, Katsura S, Shirasawa B, Hamano K Freezing of cell sheets using a 3D freezer produces high cell viability after thawing Biochemistry and Biophysics Reports 28:101169 2021

2020

  1. Nagase T, Ueno K, Mizoguchi T, Samura M, Harada T, Suehiro K, Shirasawa B, Morikage N, Hamano K.  Allogeneic fibroblast sheets accelerate cutaneous wound healing equivalent to autologous fibroblast sheets in mice American Journal of Translational Research 12:2652-2663 2020

2019

  1. Fujita A, Ueno K, Saito T, Yanagihara M, Kurazumi H, Suzuki R, Mikamo A, Hamano K.  “Hypoxic-conditioned cardiosphere-derived cell sheet transplantation for chronic myocardial infarction” European Journal of Cardio-Thoracic Surgery 56:1062-1074 2019

2018

  1. Mizoguchi T, Ueno K, Takeuchi Y, Samura M, Suzuki R, Murata T, Hosoyama T, Morikage N, Hamano K Treatment of cutaneous ulcers with multilayered mixed sheets of autologous fibroblasts and peripheral blood mononuclear cells Cellular Physiology and Biochemistry 47:201-211 2018
  2. Mizoguchi T, Ueno K, Yanagihara M, Samura M, Kurazumi H, Suzuki R, Morikage N, Hamano K Autologous fibroblasts, peripheral blood mononuclear cells, and fibrin glue accelerate healing of refractory cutaneous ulcers in diabetic mice American Journal of Translational Research 10:2920-2928 2018

2017

  1. Samura M, Hosoyama T, Takeuchi Y, Ueno K, Morikage N, Hamano K.  Therapeutic strategies for cell-based neovascularization in critical limb ischemia.  Journal of Translational Medicine 15:49 2017
  2. Tanaka Y, Hosoyama T, Mikamo A, Kurazumi H, Nishimoto A, Ueno K, Shirasawa B, Hamano K.  Hypoxic preconditioning of human cardiosphere-derived cell sheets enhances cellular functions via activation of the PI3K/Akt/mTOR/HIF-1α pathway.  American Journal of Translational Research 9:664-673. 2017
  3. Takeuchi Y, Ueno K, Mizoguchi T, Samura M, Harada T, Oga A, Murata T, Hosoyama T, Morikage N, Hamano K Ulcer Healing Effect of Autologous Mixed Sheets Consisting of Fibroblasts and Peripheral Blood Mononuclear Cells in Rabbit Ischemic Hind Limb American Journal of Translational Research 9:2340-2351. 2017
  4. Takeuchi Y, Ueno K, Mizoguchi T, Samura M, Harada T, Oga A, Murata T, Hosoyama T, Morikage N, Hamano K.  Development of Novel Mouse Model of Ulcers Induced by Implantation of Magnets Scientific Reports 7:4843. 2017

2016

  1. Samura M, Morikage N, Suehiro K, Tanaka Y, Nakamura T, Nishimoto A, Ueno K, Hosoyama T, Hamano K Combinatorial Treatment with Apelin-13 Enhances the Therapeutic Efficacy of a Preconditioned Cell-Based Therapy for Peripheral Ischemia Scientific Reports 6:19379 2016
  2. Ueno K, Takeuchi Y, Samura M, Tanaka Y, Nakamura T, Nishimoto A, Murata T, Hosoyama T, Hamano K Treatment of refractory cutaneous ulcers with mixed sheets consisting of peripheral blood mononuclear cells and fibroblasts Scientific Reports  6:28538 2016
  3. Tanaka Y, Shirasawa B, Takeuchi Y, Kawamura D, Nakamura T, Samura M, Nishimoto A, Ueno K, Morikage N, Hosoyama T, Hamano K.  Autologous preconditioned mesenchymal stem cell sheets improve left ventricular function in a rabbit old myocardial infarction model American Journal of Translational Research 8:2222-33 2016
  4. Ueno K, Samura M, Nakamura T, Tanaka Y, Takeuchi Y, Kawamura D, Takahashi M, Hosoyama T, Morikage N, Hamano K.  “Increased plasma VEGF levels following ischemic preconditioning areassociated with downregulation of miRNA-762 and miR-3072-5p” Scientific Reports 6:36758 2016

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