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研究業績

論文

獲得資金

論文

  • Shimizu F, et al, TRIM21 autoantibodies are associated with blood-brain barrier dysfunction in a subgroup of neuromyelitis optica spectrum disorder., Acta Neuropathol Commun. 2026 May 4. doi: 10.1186/s40478-026-02307-w. Online ahead of print.PMID: 42083043 (IF 6.200)
  • Yang F, et al., Aberrant laminin signaling drives melanocyte dedifferentiation and unveils a tractable therapeutic target in vitiligo., Nat Commun. 2026 Apr 17. doi: 10.1038/s41467-026-72064-w. Online ahead of print.PMID: 41997929 (IF 17.694)

  • Liu Y, et al., SFK Inhibition Suppresses EBV-Encoded BART miRNAs and Induces Apoptosis in EBV-Positive Gastric Epithelial Cells., Cancers (Basel). 2026 Mar 26;18(7):1082. doi: 10.3390/cancers18071082.PMID: 41976305 (IF 6.575)

  • Fujikawa H, et al., Antimicrobial effect and safety of 228 nm far-UVC light-emitting diodes., J Photochem Photobiol B. 2026 Mar 4;278:113410. doi: 10.1016/j.jphotobiol.2026.113410. Online ahead of print. (IF 6.814)

  • Shimizu F, Sato R,Mizukami Y, Watanabe K, Maeda T, Kanda T, Matsui N, Misawa S, Izumi Y, Kuwabara S, Nakamori M., Blood-Nerve Barrier Break down Induced by Immunoglobulin G in Typical and Multifocal Chronic Inflammatory Demyelinating Polyneuropathy and Multifocal Motor Neuropathy, Int J Mol Sci. 2026 Jan 22;27(2):1088. doi: 10.3390/ijms27021088.PMID:41596734 (IF 6.208)
  • Isayama K, Watanabe K, Ohtsuka M, Kimura S, Murata T, Honda T, Asagiri M, Sato S, Tamura H, Sugino N, Mizukami Y, Reduced Akr1b7 signaling drives ovarian aging and reproductive dysfunction., iScience. 2026 Jan 19;29(2):114719. doi: 10.1016/j.isci.2026.114719. eCollection 2026 Feb 20. PMID: 41727189 (IF 4.099)
  • Fujikawa H, Shimizu Y, Nishimura M, Fujii T, Okada Y, Kawasaki K, Watanabe K,Mizukami Y, Nishikawa J., Antimicrobial effect and safety of 228 nm far-UVC light-emitting diodes., J Photochem Photobiol B. 2026 Mar 4;278:113410. doi: 10.1016/j.jphotobiol.2026.113410. Online ahead of print. (IF 6.814)
  • Horiguchi M, Yoshihara K,Mizukami Y, Watanabe K, Tsurudome Y, Ushijima K., The Diurnal Variation in Mitochondrial Gene in Human Type 2 Diabetic Mesenchymal Stem Cell Grafts., Int J Mol Sci 2025 Jan 16;26(2):719. doi: 10.3390/ijms26020719.PMID: 39859433 (IF 6.208)
  • Nishida N, Otsu M, Mizutani Y, Ishitsuka A,Mizukami Y, Inoue S., The glycoprotein GPNMB protects against oxidative stress through enhanced PI3K/Akt signaling in epidermal keratinocytes., J Biol Chem 2025 Feb 11:108299. doi: 10.1016/j.jbc.2025.108299. Online ahead of print.PMID: 39947468, (IF 5.485)
  • Nishibori S, Chijiwa A, Kambayashi S, Iwatani N, Sakai A, Isayama K,Mizukami Y, Shiranaga N, Mizuno T, Igase M., Sodium ferrous citrate in 5-Aminolevulinic acid supplements suppresses the effector function of feline lymphocytes by reducing the mitochondrial membrane potential, Res Vet Sci 2025 Feb 28;187:105603. doi: 10.1016/j.rvsc.2025.105603. Online ahead of print. PMID:40048774 (IF 2.554)
  • Taguchi A, Uraki S, Akiyama M, Nagaon Y, Watanabe K, Mizukami Y, Ohta Y, Unexplained Hypokalemia in a Patient With Obesity Harboring an Armadillo Repeat-Containing 5 (ARMC5) Gene Variant: A Case Report, Cureus 2025 Feb 19;17(2):e79326. doi: 10.7759/cureus.79326. eCollection 2025 Feb. PMID: 40130155 (IF 1.2)
  • Shimizu F, Koga M,Mizukami Y, Watanabe K, Sato R, Takeshita Y, Maeda T, Kanda T, Nakamori M, Small Nuclear Ribonucleoprotein Autoantibody Associated With Blood-Nerve Barrier Breakdown in Guillain-Barré Syndrome., Neurol Neuroimmunol Neuroinflamm. 2025 Jul;12(4):e200405. doi: 10.1212/NXI.0000000000200405. Epub 2025 May 19.PMID: 40388674 (IF 8.485)
  • Matsumoto Y, Hitaka Y, Hirata H, Yamamoto Y, Kobayashi K, Isoyama N, Matsubara T, Watanabe K,Mizukami Y, Nakagawa S, Mishima K, Harada K, Shiraishi K., Exploration of predictive factors based on oral and intestinal bacterial flora for treating patients with urothelial carcinoma., PLoS One. 2025 Jun 18;20(6):e0324814. doi: 10.1371/journal.pone.0324814. eCollection 2025.PMID: 40532026 Free PMC article. (IF 3.752)
  • Uno E, Kim F, Yoshino M, Sato Y, Hashimoto M, Watanabe K,Mizukami Y, Muto J.Targeting inflammatory macrophages with hyaluronan tetrasaccharide: effects on fibroblast collagen degradation and synthesis., Front Immunol. 2025 Jun 5;16:1592751. doi: 10.3389/fimmu.2025.1592751. eCollection 2025.PMID: 40539048 Free PMC article. (IF 5.7)
  • Harada K, Ferdous T, Kawasaki K, Watanabe K,Mizukami Y., Effects of aged garlic extract may differ between normal cells and cancer cells., Biomed Rep. 2025 Jul 1;23(3):150. doi: 10.3892/br.2025.2028. eCollection 2025 Sep.PMID:40630139 (IF 2.3)
  • Roose SK,Mizukami Y, Muto J, Okano H, Nakamura M, Nagoshi N., Trehalose enhances neuronal differentiation with VEGF secretion in human iPSC-derived neural stem/progenitor cells., Regen Ther. 2025 Jun 26;30:268-277. doi: 10.1016/j.reth. 2025.06.012. eCollection 2025 Dec.PMID: 40654519 Free PMC article. (IF 3.4)
  • Tagami M, Isayama K, Nishio M, Yoshikawa A, Misawa N, Sakai A, Haruna Y, Tomita M,Mizukami Y, Azumi A, Honda S., Gene expression cluster differences and molecular correlation with the STING pathway in orbital MALT lymphoma and orbital IgG4-related eye disease., Discov Oncol. 2025 Aug 4;16(1):1466. doi: 10.1007/s12672-025-03239-y.PMID: 40759841 (IF 2.72)
  • Fujii A, Nakabayashi H, Nagao Y, Akiyama M, Taguchi A, Yorimoto K, Hamada R, Saeki I, Yamamoto N, Takami T, Watanabe K,Mizukami Y, Ohta Y., Early-onset diabetes with low utilization of lipid as an energy source carrying a rare missense mutation in the CEL gene. Endocrinol Diabetes Metab Case Rep. 2025 Aug 18;2025(3):e240151. doi: 10.1530/EDM-24-0151. Print 2025 Aug 1. PMID:40840513 (IF 0.8)
  • Wanjiru DK, Niyonzima YB,Mizukami Y, Kadokawa H., Aging-associated transcriptomic changes in the bovine endometrium., Gene 2025 Sep 16:149764. doi: 10.1016/j.gene.2025.149764. Online ahead of print.PMID:40967285 (IF 3.913)
  • Kawasaki K, Harada K, Ferdous T, Isayama K, Watanabe K,Mizukami Y, Mishima K. The Healing Effect of Aged Garlic Extract on Acetic Acid and 5-Fluorouracil-Induced Oral Mucositis in Mice., J Clin Med Res. 2025 Oct 29;17(10):582-594. doi: 10.14740/jocmr6341. eCollection 2025 Oct.PMID: 41209580 (IF 1.73)
  • Ota K, Takahashi T, Nitta E, Watanabe K, Isayama K, Morimoto Y, Tsuji K, Matsuyama Y, Matsuyama T, Ota Y, Kanenishi K,Mizukami Y, Shimoya K., Spontaneous ovarian hyperstimulation in a nonpregnant woman with PCOS: a rare case highlighting FMN2 missense mutation and androgen receptor gene deletion., J Ovarian Res. 2025 Nov 10;18(1):246. doi: 10.1186/s13048-025-01863-4.PMID: 41214804 (IF 5.506)
  • Matsuya S, Imai H, Iwamori N, Fujino K, Sakurai Y, Yoshimura T, Watanabe K, Fujii W,Mizukami Y, Tsujio M, Kusakabe KT, Kano K., Induction of pluripotency in large Japanese field mouse (Apodemus speciosus) fibroblasts via reprogramming., J Vet Med Sci. 2025 Dec 22. doi: 10.1292/jvms.25-0390. Online ahead of print.PMID: 41423246 (IF1.105)
  • Horii T, Morita S, Hino S, Hino Y, Fukushima HS, Kobayashi R, Kimura M, Nakao M,Mizukami Y, Inoue A, Hatada I., Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice., Nat Commun. 2025 Dec 25;16(1):11200. doi: 10.1038/s41467-025-67488-9.PMID: 41449196 Free PMC article. (IF 17.694) (2025)
  • Doi K, Hirano T, Tominaga N, Watanabe K, Oishi K, Fukatsu-Chikumoto A, Yamamoto T, Ohteru Y, Hamada K, Murata Y, Asami-Noyama M, Edakuni N, Kakugawa T,Mizukami Y, Matsunaga K., Small RNA Profiles of Serum-Derived Extracellular Vesicles in the Comorbid Condition of Frailty and Obstructive Pulmonary Disease: An Observational, Cross-Sectional Study., 2025 Nov 28;15(12):1663. doi: 10.3390/biom15121663.PMID: 41463319 (IF 6.064)

獲得資金

  • 令和5年-令和8年　科研基盤A (代表 水上洋一) 3720万円　心臓老化のゲノムDNAを解明する 心臓の老化を制御する遺伝子修飾及び遺伝子変異の関係をロングリードシークエンスで解明し、心臓の老化が進む原因因子を明らかにしている。

 

  • 令和4年　やまぐち振興財団　地鶏の筋繊維及び受精卵の解析並びに解析に伴うデータ通信の計測　(代表 水上洋一) 316万円 山口県産地鶏のイミダゾールペプチドを増加する遺伝子変異を解明し、機能性食品の開発に成功した。

 

 

  • 令和4年　やまぐち振興財団　病魚介類の解析及び河川調査におけるメタバーコーティング解析　(代表 水上洋一) 94万円 山口県内の河川に存在する魚類遺伝子解析の結果から下流内に存在する魚類の変動を明らかにする技術を確立した。

 

  • 令和4年-6年 文科省　科研　挑戦的研究（萌芽）(課題番号　22K19711) ヒト全ゲノム解析を用いて染色体に挿入された老化ウイルスを解明する （代表 水上洋一）490万円 子宮内ゲノムDNAに存在するウィルス遺伝子を同定し、染色体の活性を制御するウィルス遺伝子の存在を明らかにした。

 

  • 令和3年-5年　科研基盤B (課題番号21H03358) 老化による心筋症変異ゲノム編集マウスの分泌小胞における全遺伝子解析 （代表　水上洋一）1440万円 心筋症の分泌小胞内の全miRNA解析に成功し、心筋症と全身状態との関連しを明らかにした。