業績

教授

玉田　耕治

准教授

佐古田　幸美

講師

安達　圭志

助教

城﨑　幸介

教授玉田　耕治

2023

• Anami T, Pan C, Fujiwara Y, Komohara Y, Yano H, Saito Y, Sugimoto M, Wakita D, Motoshima T, Murakami Y, Yatsuda J, Takahashi N, Suzu S, Asano K, Tamada K, Kamba T.
  Dysfunction of sinus macrophages in tumor-bearing host induces resistance to immunotherapy, Cancer Sci. 2024 Jan;115(1):59-69. doi: 10.1111/cas.16003. Epub 2023 Nov 3.
• Sasaki T, Sakoda Y, Adachi K, Tokunaga Y, Tamada K.
  Therapeutic effects of anti-GM2 CAR-T cells expressing IL-7 and CCL19 for GM2-positive solid cancer in xenograft model, Cancer Med, 2023 Apr. doi: 10.1002/cam4.5907. Online ahead of print.
• Nakajima M, Hazama S, Tokumitsu Y, Shindo Y, Matsui H, Matsukuma S, Nakagami Y, Tamada K, Udaka K, Sakamoto M, Saito A, Kouki Y, Uematsu T, Ming Xu, Iida M, Tsunedomi R, Suzuki N, Takeda S, Ioka T, Doi S, Nagano H.
  Phase I study of a novel therapeutic vaccine as perioperative treatment for patients with surgically resectable hepatocellular carcinoma: The YCP02 trial, Hepatol Res, 2023 Jun;12(11):12569-12580. doi: 10.1002/cam4.5907. Epub 2023 Apr 9.

2022

• Adachi K, Tamada K.
  Paving the road to make chimeric antigen receptor-Tcell therapy effective against solid tumors, Cancer Sci, 2022 Dec;113(12):4020-4029.
• Ohta K, Sakoda Y, Tamada K.
  Novel technologies for improving the safety and efficacy of CAR-T cell therapy, Int J Hematol. 2023 May;117(5):647-651. Epub 2022 Oct 29.
• Yonemitsu K, Cheng Pan, Fujiwara Y, Miyasato Y, Shiota T, Yano H, Hosaka S, Tamada K, Yamamoto Y, Komohara Y.
  GM-CSF derived from the inflammatory microenvironment potentially enhanced PD-L1 expression on tumor-associated macrophages in human breast cancer. 2022 Jul;12(1):12007, doi: 10.1038/s41598-022-16080-y.
• Tokunaga Y, Sasaki T, Goto S, Adachi K, Sakoda Y, Tamada K.
  Enhanced anti-tumor responses of tumor antigen-specific TCR-T cells genetically engineered to produce IL-7 and CCL19, Mol Cancer Ther. 2022 Jan;21(1):138-148.

2021

• Samoto M, Matsuyama H, Matsumoto H, Hirata H, Ueno K, Ozawa S, Mori J, Inoue R, Yano S, Yamamoto Y, Haginaka J, Horiyama S, Tamada K.
  Novel bone microenvironment model of castration-resistant prostate cancer with chitosan fiber matrix and osteoblasts. Oncol Lett, 2021 Oct;22(4):689.
• Matsusaka K, Fujiwara Y, Cheng Pan, Esumi S, Saito Y, Jing Bi, Nakamura Y, Mukunoki A, Takeo T, Nakagata N, Yoshii D, Fukuda R, Nagasaki T, Tanaka R, Komori H, Maeda H, Watanabe H, Tamada K, Komohara Y, Maruyama T.
  α1-acid glycoprotein enhances the immunosuppressive and protumor functions of tumor-associated macrophages. Cancer Res, 2021 Jul;canres.3471. 2021 Sep;81(17):4545-4559.
• Takahashi H, Okayama N, Yamaguchi N1, Nomura M, Miyahara Y, M H Mahbub, Hase R, Morishima Y, Suehiro Y, Yamasaki T, Tamada K, Takahashi S, Tojo A, Tanabe T.
  Analysis of Relationships between Immune Checkpoint and Methylase Gene Polymorphisms and Outcomes after Unrelated Bone Marrow Transplantation. Cancers (Basel) , 2021 Jun;13(11):2752.
• Hirano T, Honda T, Kanameishi S, Honda Y, Egawa G, Kitoh A, Nakajima S, Otsuka A, Nomura T, Dainichi T, Yaguchi T, Inozume T, Kataoka T, Tamada K, Kabashima K.
  PD-L1 on mast cells suppresses effector CD8 + T-cell activation in the skin in murine contact hypersensitivity. J Allergy Clin Immunol. 2021 Aug;148(2):563-573.e7.
• Goto S, Sakoda Y, Adachi K, Sekido Y, Yano S, Eto M, Tamada K.
  Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models. Cancer Immunol Immunother. 2021 Sep;70(9):2503-2515. Epub 2021 Feb.
• Mori J, Adachi K, Sakoda Y, Sasaki T, Goto S, Matsumoto H, Nagashima Y, Matsuyama H, Tamada K.
  Anti-tumor efficacy of human anti-c-met CAR-T cells against papillary renal cell carcinoma in an orthotopic model. Cancer Sci. 2021 Apr;112(4):1417-1428.

2020

• Mizumoto Y, Hemmi H, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Nakamura M, Hayata K, Fukuda-Ohta Y, Sugiyama M, Ohta T, Orimo T, Okura S, Sasaki I, Tamada K, Yamaue H, Kaisho T.
  Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade. Br J Cancer. 2020 Apr;122(8):1185-1193.
• Nakajima M, Hazama S, Tamada K, Udaka K, Kouki Y, Uematsu T, Arima H, Saito A, Doi S, Matsui H, Shindo Y, Matsukuma S, Kanekiyo S, Tokumitsu Y, Tomochika S, Iida M, Yoshida S, Nakagami Y, Suzuki N, Takeda S, Yamamoto S, Yoshino S, Ueno T, Nagano H.
  A phase I study of multi-HLA-binding peptides derived from heat shock protein 70/glypican-3 and a novel combination adjuvant of hLAG-3Ig and Poly-ICLC for patients with metastatic gastrointestinal cancers: YNP01 trial. Cancer Immunol Immunother. 2020 Aug; 69(8):1651-1662.
• Ueda T, Kumagai A, Iriguchi S, Yasui Y, Miyasaka T, Nakagoshi K, Nakane K, Saito K, Takahashi M, Sasaki A, Yoshida S, Takasu N, Seno H, Uemura Y, Tamada K, Nakatsura T, Kaneko S.
  Non-clinical efficacy, safety and stable clinical cell processing of induced pluripotent stem cell-derived anti-glypican-3 chimeric antigen receptor-expressing natural killer/innate lymphoid cells. Cancer Sci. 2020 Mar;111(5):1478-1490.
• Ohkuma R, Yada E, Ishikawa S, Komura D, Ishizaki H, Tamada K, Kubota Y, Hamada K, Ishida H, Hirasawa Y, Ariizumi H, Satoh E, Shida M, Watanabe M, Onoue R, Ando K, Tsurutani J, Yoshimura K, Yokobori T, Sasada T, Aoki T, Murakami M, Norose T, Ohike N, Takimoto M, Izumizaki M, Kobayashi S, Tsunoda T, Wada S.
  High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer. PLoS One. 2020 Jan;15(1):e0226707.

2019

• Nakajima M, Tamada K.
  Cancer Immunotherapy Targeting Co-signal Molecules. Adv Exp Med Biol. 2019;1189:313-326.
• Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K.
  Improved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells. Cancer Sci. 2019 Oct;110(10):3079-3088.
• Matsui H, Hazama S, Tamada K, Udaka K, Irie A, Nishimura Y, Miyakawa T, Doi S, Nakajima M, Kanekiyo S, Tokumitsu Y, Shindo Y, Tomochika S, Yoshida S, Iida M, Suzuki N, Takeda S, Yamamoto S, Yoshino S, Ueno T, Nagano H.
  Identification of a Promiscuous Epitope Peptide Derived From HSP70. J. Immunother. 2019 Sep;42(7):244-250.
• Yamauchi A, Tone T, Sugimoto K, Seok Lim H, Kaku T, Tohda C, Shindo T, Tamada K, Mizukami Y, Hirano E.
  Porcine placental extract facilitates memory and learning in aged mice. Food Sci Nutr. 2019 Aug ;7(9):2995-3005.
• Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
  Inhibitoryfunctions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murinetumor microenvironment. Cancer Immunol. Immunother. 2019 Feb;68(2):201-211.

2018

• Mizumoto Y, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Hemmi H, Tamada, K, Kaisho T, Yamaue H.
  In vivo antigen delivery to dendritic cells-a novel peptide vaccine for cancer therapy. Gan To Kagaku Ryoho. 2018 Oct;45(10):1469-1471.
• Okadome J, Matsumoto T, Yoshiya K, Matsuda D, Tamada, K, Onimaru M, Nakano K, Egashira K, Yonemitsu Y, Maehara Y.
  BubR1 insufficiency impairs angiogenesis in aging and in experimental critical limb ischemic mice. J. Vasc. Surg. 2018 Aug;68(2):576-586.e1.
• Adachi K, Tamada K.
  Microbial biomarkers for immune checkpoint blockade therapy against cancer. J. Gastroenterol. 2018 Sep; 53(9):999–1005.
• Hazama S, Tamada K, Yamaguchi Y, Kawakami Y, Nagano H.
  Current status of immunotherapy against gastrointestinal cancers and its biomarkers: Perspective for precision immunotherapy. Ann. Gastroenterol. Surg. 2018 Jun;2(4):289–303.
• Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K.
  IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat. Biotechnol. 2018 Apr;36(4):346-351.
• Herro R, Shui JW, Zahner S, Sidler D, Kawakami Y, Kawakami T, Tamada K, Kronenberg M, Croft M.
  LIG HT-HVEM signaling in keratinocytes controls development of dermatitis. J. Exp. Med. 2018 Feb;5;215(2):415-422.

2017

• Takahashi H, Okayama N, Yamaguchi N, Miyahara Y, Morishima Y, Suehiro Y, Yamasaki T, Tamada K, Takahashi S, Tojo A, Asano S, Tanabe T.
  Associations of interactions between NLRP3 SNPs and HLA mismatch with acute and extensive chronic graft-versus-host diseases. Sci. Rep. 2017 Oct;12;7(1):13097.

2016

• Ishibashi M, Tamura H, Sunakawa M, Kondo-Onodera A, Okuyama N, Hamada Y, Moriya K, Choi I, Tamada K, Inokuchi K.
  Myeloma Drug Resistance Induced by Binding of Myeloma B7-H1 (PD-L1) to PD-1. Cancer Immunol. Res. 2016 Sep;4(9):779-788.
• Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K.
  Combined adjuvants of poly(I:C) plus LAG-3-Ig improve anti-tumor effects of tumor-specific T cells preventing their exhaustion. Cancer Sci. 2016 Apr;107(4):398-406.
• Sakoda Y, Nagai T, Murata S, Mizuno Y, Kurosawa H, Shoda H, Morishige N, Yanai R, Sonoda KH, Tamada K.
  Pathogenic Function of Herpesvirus Entry Mediator in Experimental Autoimmune Uveitis by Induction of Th1- and Th17-Type T Cell Responses. J. Immunol. 2016 Apr;196(7):2947-2954.
• Zhu Y, Yao S, Augustine MM, Xu H, Wang J, Sun J, Broadwater M, Ruff W, Luo L, Zhu G, Tamada K, Chen L.
  The SALM5-HVEM interaction limits inflammation and contributes to immune privilege in the CNS. Sci. Adv. 2016 Apr;2(4):e1500637.

2015

• Shoda H, Yanai R, Yoshimura T, Nagai T, Kimura K, Sobrin L, Connor KM, Sakoda Y, Tamada K, Ikeda T, Sonoda KH.
  Dietary Omega-3 Fatty Acids Suppress Experimental Autoimmune Uveitis in Association with Inhibition of Th1 and Th17 Cell Function. PLoS One, 2015 Sep;10(9):e0138241.
• Herro R, Da Silva Antunes R, Aguilera AR, Tamada K, Croft M.
  Tumor necrosis factor superfamily 14 (LIGHT) controls thymic stromal lymphopoietin to drive pulmonary fibrosis. J. Allergy Clin. Immunol. 2015 Sep;136(3):757-768.
• Adachi K, Tamada K.
  Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy. Cancer Sci. 2015 Aug;106(8):945-950.
• Maeda Y, Yoshimura K, Matsui H, Shindo Y, Tamesa T, Tokumitsu Y, Hashimoto N, Tokuhisa Y, Sakamoto K, Sakai K, Suehiro Y, Hinoda Y, Tamada K, Yoshino S, Hazama S, Oka M.
  Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial. Cancer Immunol. Immunother. 2015 Aug;64(8):1047-1056.
• Herro R, Da Silva Antunes R, Aguilera AR, Tamada K, Croft M.
  The Tumor Necrosis Factor Superfamily Molecule LIGHT Promotes Keratinocyte Activity and Skin Fibrosis. J. Invest. Dermatol. 2015 Aug;135(8):2109-2118.
• Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L.
  B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets. PLoS One. 2015 Jun;10(6):e0130126.
• Tongu M, Harashima N, Tamada K, Chen L, Harada M.
  Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state. Cancer Sci. 2015 Jan;106(1):9-17.
• Shindo Y, Yoshimura K, Kuramasu A, Watanabe Y, Ito H, Kondo T, Oga A, Ito H, Yoshino S, Hazama S, Tamada K, Yagita H, Oka M.
  Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor. Anticancer Res. 2015 Jan;35(1):129-136.

2014

• Maeda N, Yoshimura K, Yamamoto S, Kuramasu A, Inoue M, Suzuki N, Watanabe Y, Maeda Y, Kamei R, Tsunedomi R, Shindo Y, Inui M, Tamada K, Yoshino S, Hazama S, Oka M.
  Expression of B7-H3, a potential factor of tumor immune evasion in combination with the number of regulatory T cells, affects against recurrence-free survival in breast cancer patients. Ann. Surg. Oncol. 2014 Dec; 21 Suppl 4:S546-554.
• Watanabe Y, Yoshimura K, Yoshikawa K, Tsunedomi R, Shindo Y, Matsukuma S, Maeda N, Kanekiyo S, Suzuki N, Kuramasu A, Sonoda K, Tamada K, Kobayashi S, Saya H, Hazama S, Oka M.
  A stem cell medium containing neural stimulating factor induces a pancreatic cancer stem-like cell-enriched population. Int. J. Oncol. 2014 Nov;45(5):1857-1866.
• Cairo C, Surendran N, Harris KM, Mazan-Mamczarz K, Sakoda Y, Diaz-Mendez F, Tamada K, Gartenhaus RB, Mann DL, Pauza CD.
  Vγ2Vδ2 T cell Costimulation Increases NK cell Killing of Monocyte-derived Dendritic Cells. Immunology. 2014 Sep;144(3):422-430.
• Tamada K.
  Development of novel immunotherapy targeting cancer immune evasion. Gan To Kagaku Ryoho. 2014 Sep;41(9):1062-1065.
• Sakoda Y, Tamada K.
  Development of cancer immunotherapy by next generation multi-targeting CAR-T cells. Rinsho Ketsueki. 2014 Jun;55(6):651-656.
• Adachi K, Nakamura R, Osada Y, Senba M, Tamada K, Hamano S.
  Involvement of IL-18 in the expansion of unique hepatic T cells with unconventional cytokine profiles during Schistosoma mansoni infection. PLoS One. 2014 May;9(5):e96042.
• Song C, Sadashivaiah K, Furusawa A, Davila E, Tamada K, Banarjee A.
  Eomesodermin is required for antitumor immunity mediated by 4-1BB-agonist immunotherapy. OncoImmunology. 2014 Jan;3(1):e27680.

2013

• Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S.
  Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection. PLoS One. 2013 Dec;8(12):e82698.
• Haile ST, Dalal SP, Clements V, Tamada K, Ostrand-Rosenberg S.
  Soluble CD80 Restores T Cell Activation and Overcomes Tumor Cell Programmed Death Ligand 1-Mediated Immune Suppression. J. Immunol. 2013 Sep;191(5):2829-2836.
• Goding SR, Wilson KA, Xie Y, Harris KM, Baxi A, Akpinarli A, Fulton A, Tamada K, Strome SE, Antony PA.
  Restoring Immune Function of Tumor-Specific CD4+ T Cells during Recurrence of Melanoma. J. Immunol. 2013 May;190(9):4899-4909.
• Tamura H, Ishibashi M, Yamashita T, Tanosaki S, Okuyama N, Kondo A, Hyodo H, Shinya E, Takahashi H, Dong H, Tamada K, Chen L, Dan K, Ogata K.
  Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma. Leukemia. 2013 Feb;27(2):464-72.
• Xu D, Fu HH, Obar JJ, Park JJ, Tamada K, Yagita H, Leffancois L.
  A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection. PLoS One. 2013 Feb;8(2):e56539.

2012

• Tamada K, Geng D, Sakoda Y, Bansal N, Srivastava R, Davila E.
  Redirecting gene-modified T cells toward various cancer types using tagged antibodies. Clin. Cancer Res. 2012 Dec;18(23):6436-6445.
• Jain A, Olsen HS, Vyzasatya R, Burch E, Sakoda Y, Merigeon EY, Cai L, Lu C, Tan M, Tamada K, Schulze D, Block DS, Strome SE.
  Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice. Arthritis Res. Ther. 2012 Aug;14(4):R192.
• Olino K, Wada S, Edil BH, Pan X, Meckel K, Weber W, Slansky J, Tamada K, Lauer P, Brockstedt D, Pardoll D, Schulick R, Yoshimura K.
  Tumor-associated antigen expressing listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases. Ann. Surg. Oncol. 2012 Jul;19 Suppl 3:S597-607.
• Park JJ, Anand S, Zhao Y, Matsumura Y, Sakoda Y, Kuramasu A, Strome SE, Chen L, Tamada K.
  Expression of anti-HVEM single chain antibody on tumor cells induces tumor-specific immunity with long-term memory. Cancer Immunol. Immunother. 2012 Feb;61(2):203-214.
• Galante A, Tamada K, Levy D.
  B7-H1 and a mathematical model for cytotoxic T cell and tumor cell interaction. Bull. Math. Biol. 2012 Jan;74(1):91-102.

2011

• Haque M, Hou JS, Hisamichi K, Tamada K, Cusack CA, Abdelmalek M, Brown RE, Vonderheid EC.
  Cutaneous and systemic plasmacytosis vs. cutaneous plasmacytic castleman disease: Review and speculations about pathogenesis. Clin. Lymphoma Myeloma Leuk. 2011 Dec;11(6):453-461.
• Sakoda Y, Anand S, Zhao Y, Park JJ, Liu Y, Kuramasu A, van Rooijen N, Chen L, Strom SE, Hancock WW, Chen L, Tamada K.
  Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J. Clin. Invest. 2011 Dec;121(12):4810-4819.
• Stanley AC, Rivera FL, Haque A, Sheel M, Zhou Y, Amante FH, Bunn PT, Randall LM, Pfeffer K, Scheu S, Hickey MJ, Saunders B, Ware C, Hill GR, Tamada K, Kaye PM, Engwerda CR.
  Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection. PLoS Pathog. 2011 Oct;7(10):e1002279.
• Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue JI, Akiyama T, Matsumoto M.
  Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J. Immunol. 2011 May;186(9):5047-5057.
• Sakoda Y, Park JJ, Zhao Y, Kuramasu A, Geng D, Liu Y, Davila E, Tamada K.
  Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway. Blood. 2011 Feb;117(8):2506-2514.

2010

• Kim YS, Park JJ, Sakoda Y, Zhao Y, Hisamichi K, Kaku T, Tamada K.
  Preventive and therapeutic potential of placental extract in contact hypersensitivity. Int. Immunopharmacol. 2010 Oct;10(10):1177-1184.
• Park JJ, Omiya R, Matsumura Y, Sakoda Y, Kuramasu A, Augustine MM, Yao S, Tsushima F, Narazaki H, Anand S, Liu Y, Strome SE, Chen L, Tamada K.
  B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T cell tolerance. Blood. 2010 Aug;116(8):1291-1298.
• Kondo A, Yamashita T, Tamura H, Zhao W, Tsuji T, Shimizu M, Shinya E, Takahashi H, Tamada K, Chen L, Dan K, Ogata K.
  Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes. Blood. 2010 Aug;116(7):1124-1131.
• Zhang X, Voskens CJ, Sallin M, Maniar A, Montes CL, Zhang Y, Lin W, Li G, Burch E, Tan M, Hertzano R, Chapoval AI, Tamada K, Gastman BR, Schulze DH, Strome SE.
  CD137 promotes proliferation and survival of human B cells. J. Immunol. 2010 Jan;184(2):787-795.

2009

• Omiya R, Tsushima F, Narazaki H, Sakoda Y, Kuramasu A, Kim Y, Xu H, Tamura H, Zhu G, Chen L, Tamada K.
  Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity. Immunology. 2009 Dec;128(4):543-555.
• Yao S, Wang S, Zhu Y, Luo L, Zhu G, Flies S, Xu H, Ruff W, Broadwater M, Choi IH, Tamada K, Chen L.
  PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood. 2009 Jun;113(23):5811-5818.
• Zhu G, Augustine MM, Azuma T, Luo L, Yao S, Anand S, Rietz AC, Huang J, Xu H, Flies AS, Flies SJ, Tamada K, Colonna M, van Deursen JM, Chen L.
  B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood. 2009 Feb;113(8):1759-1767.

2008

• Randall LM, Amante FH, Zhou Y, Stanley AC, Haque A, Rivera F, Ware C, Tamada K, Engwerda CR.
  Selective blockade of LIGHT-LTbR signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA. J. Immunol. 2008 Dec;181(11):7458-7462.
• Lin W, Voskens CJ, Zhang X, Schindler DG, Wood A, Wei Y, Burch E, Tamada K, Chen L, Wang LX, Schulze DH, Mann D, Strome SE.
  Fc dependent expression of CD137 on human NK cells: insights into “agonistic” effects of anti-CD137 monoclonal antibodies. Blood. 2008 Aug;112(3):699-707.

2007

• Tsushima F, Yao S, Shin T, Flies A, Flies S, Xu H, Tamada K, Pardoll DM, Chen L.
  Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood. 2007 Jul;110(1):180-185.
• Xu Y, Flies AS, Flies DB, Zhu G, Anand S, Flies SJ, Xu H, Anders R, Hancock WW, Chen L, Tamada K.
  Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood. 2007 May;109(9):4097-4104.
• Xu Y, Tamada K, Chen L.
  LIGHT-related molecular network in the regulation of innate and adaptive immunity. Immunol. Res. 2007;37(1):17-32.

2006

• Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y,
  Pardoll DM, Chen L, Tamada K. Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis. J. Clin. Invest. 2006 Apr;116(4):1045-1051.

2005

• Tamura H, Dan K, Tamada K, Nakamura K, Shioi Y, Hyodo H, Wang SD, Dong H, Chen L, Ogata K.
  Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Clin. Cancer Res. 2005 Aug;11(16):5708-5717.
• Vassallo R, Tamada K, Lau JS, Kroening PR, Chen L.
  Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming. J. Immunol. 2005 Aug;175(4):2684-2691.
• Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, Tamada K, Chen L.
  Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 2005 Feb;65(3):1089-1096.

2004

• Luo L, Chapoval AI, Flies DB, Zhu G, Hirano F, Wang S, Lau JS, Dong H, Tamada K, Flies AS, Liu Y, Chen L.
  B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. J. Immunol. 2004 Nov;173(9):5445-5450.
• Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J.
  53BP1 is required for class switch recombination. J. Cell Biol. 2004 May;165(4):459-464.
• Hisada M, Yoshimoto T, Kamiya S, Magami Y, Miyaji H, Yoneto T, Tamada K, Aoki T, Koyanagi Y, Mizuguchi J.
  Synergistic antitumor effect by coexpression of chemokine CCL21/SLC and costimulatory molecule LIGHT. Cancer Gene Ther. 2004 Apr;11(4):280-288.
• Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L.
  B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity. 2004 Mar;20(3):327-336.
• Wilcox RA, Tamada K, Flies DB, Zhu G, Chapoval AI, Blazar BR, Kast WM, Chen L.
  Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo. Blood. 2004 Jan;103(1):177-184.

2003

• Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L.
  Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. J. Immunol. 2003 Nov;171(9):4650-4654.
• Strome SE, Dong H, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen L.
  B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Res. 2003 Oct;63(19):6501-6505.
• Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L.
  B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity. 2003 Jun;18(6):849-861.

2002

• Wilcox RA, Tamada K, Strome SE, Chen L.
  Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. J. Immunol. 2002 Oct;169(8):4230-4236.
• Wilcox RA, Flies DB, Wang H, Tamada K, Johnson AJ, Pease LR, Rodriguez M, Guo Y, Chen L.
  Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy. Cancer Res. 2002 Aug;62(15):4413-4418.
• Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche P, Lu J, Tamada K, Lennon VA, Celis E, Chen L.
  Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nature Med. 2002 Aug;8(8):793-800.
• Tamada K, Ni J, Zhu G, van Deursen JM, Chen L.
  Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. J. Immunol. 2002 May;168(10):4832-4835.
• Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Perdoll DM, Chen L.
  Expression of functional CD137 receptor by dendritic cells. J. Immunol. 2002 May;168(9):4262-4267.
• Wang S, Zhu G, Tamada K, Chen L, Bajorath J.
  Ligand binding sites of inducible costimulator and high avidity mutants with improved function. J. Exp. Med. 2002 Apr;195(8):1033-1041.
• Strome SE, Voss S, Wilcox R, Wakefield TL, Tamada K, Flies D, Chapoval A, Lu J, Kasperbauer JL, Padley D, Vile R, Gastineau D, Wettstein P, Chen L.
  Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res. 2002 Mar;62(6):1884-1889.
• Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L.
  Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J. Clin. Invest. 2002 Mar;109(5):651-659.
• Tamada K, Tamura H, Flies D, Fu XY, Celis E, Pease LR, Blazar BR, Chen L.
  Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. J. Clin. Invest. 2002 Feb;109(4):549-557.
• Strome SE, Martin E, Flies D, Khurana D, Salomao D, Tamada K, Chapoval AI, Kasperbauer JL, Olsen KD, Chen L.
  Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients. Otolaryngol Head Neck Surg. 2002 Feb;126(2):180-187.

2001

• Wang J, Lo JC, Foster A, Yu P, Chen HM, Wang Y, Tamada K, Chen L, Fu YX.
  The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J. Clin. Invest. 2001 Dec;108(12):1771-1780.
• Wang J, Chun T, Wu Q, Wang Y, Tamada K, Chen L, Wang CR, Fu XY.
  The critical role of LIGHT, a TNF family member, in T cell development. J. Immunol. 2001 Nov;167(9):5099-5105.
• Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu YX, Chen L.
  Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-E(alpha)-transgenic mice. J. Immunol. 2001 Sep;167(5):2671-2676.
• Sica GL, Zhu G, Tamada K, Liu D, Ni J, Chen L.
  RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB. Blood. 2001 May;97(9):2702-2707.
• Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L.
  B7-H3:a costimulatory molecule for T cell activation and IFN-γ production. Nat. Immunol. 2001 Mar;2(3):269-274.
• Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K, Chen L.
  B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood. 2001 Mar;97(6):1809-1816.

2000年以前の主な業績

• Wang SD, Zhu G, Chapoval AI, Dong H, Tamada K, Ni J, Chen L.
  Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood. 2000 Oct;96(8):2808-2813.
• Tatsugami K, Tamada K, Abe K, Harada M, Nomoto K.
  Local injections of OK432 can help the infiltration of adoptively transferred CD8+ T cells into the tumor sites and synergistically induce local production of the Th1-type cytokines and CXC3 chemokines. Cancer Immunol. Immunother. 2000 Sep;49(7):361-368.
• Strome SE, Martin B, Files D, Tamada K, Chapoval AI, Shu S, Chen L.
  Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor reactive T cells against poorly immunogenic, MHC class I-negative A9P melanoma. J. Immunother. 2000 Jul-Aug;23(4):430-437.
• Eto M, Harada M, Tamada K, Tokuda N, Koikawa Y, Nakamura M, Nomoto K, Naito S.
  Antitumor activity of interleukin-12 against murine bladder cancer. J. Urol. 2000 May;163(5):1549-1552.
• Tamada K, Shimozaki K, Chapoval AI, Zhai Y, Su J, Chen SF, Hsieh L, Nagata S, Chen L.
  LIGHT a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J. Immunol. 2000 Apr;164(8):4105-4110.
• Chapoval AI, Tamada K, Chen L.
  In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells. Blood. 2000 Apr;95(7):2346-2351.
• Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, Flies D, Boone T, Hsu H, Fu XY, Nagata S, Ni J, Chen L.
  Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway. Nature Med. 2000 Mar;6(3):283-289.
• Dong H, Zhu G, Tamada K, Chen L.
  B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nature Med. 1999 Dec;5(12):1365-1369.
• Hu S, Tamada K, Ni J, Vincenz C, Chen L.
  Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics. 1999 Nov;62(1):103-107.
• Li T, Tamada K, Abe K, Tada H, Onoe Y, Tatsugami K, Harada M, Kubo C, Nomoto K.
  The restoration of the antitumor T cell response from stress-induced suppression using a traditional chinese herbal medicine Hochu-ekki-to (TJ-41:Bu-Zhong-Yi-Qi-Tang). Immunopharmacology. 1999 Jun;43(1):11-21.
• Harada M, Tamada K, Abe K, Li T, Onoe Y, Tada H, Tatsugami K, Ando T, Kimura G, Nomoto K.
  Characterization of B16 melanoma-specific cytotoxic T lymphocytes. Cancer Immunol. Immunother. 1998 Dec;47(4):198-204.
• Onoe Y, Harada H, Tamada K, Abe K, Li T, Tada H, Nomoto K.
  Involvement of both donor cytotoxic T lymphocytes and host NK1.1+ T cells in the thymic atrophy of mice suffering from acute graft-versus-host disease. Immunology. 1998 Oct;95(2):248-256.
• Tamada K, Harada M, Abe K, Li T, Nomoto K.
  (corresponding author) IL-4-producing NK1.1+ T cells are resistant to glucocorticoid-induced apoptosis: Implications for the Th1/Th2 balance. J. Immunol. 1998 Aug;161(3):1239-1247.
• Yamada H, Ninomiya T, Hashimoto A, Tamada K, Takimoto H, Nomoto K.
  Positive selection of extrathymically developed T cells by self-antigens. J. Exp. Med. 1998 Aug;188(4):779-784.
• Harada M, Tamada K, Abe K, Yasumoto K, Kimura G, Nomoto K.
  Role of the endogenous production of interleukin 12 in immunotherapy. Cancer Res. 1998 Jul;58(14):3073-3077.
• Ito O, Harada M, Takenoyama M, Tamada K, Li T, Abe K, Fujie H, Nomoto K.
  Vaccination with activated B cells pulsed with the tumor-lysates can induce tumor-specific CD4+ T cells in vivo. Immunobiology. 1998 Jul;199(1):133-147.
• Tamada K, Harada M, Abe K, Li T, Tada H, Onoe Y, Nomoto K.
  Antitumor vaccination effect of dendritic cells can be augmented by locally utilizing Th1-type cytokines from OK432-reactive CD4+ T cells. Cancer Immunol. Immunother. 1998 May;46(3):128-136.
• Harada M, Tamada K, Abe K, Li T, Onoe Y, Tada H, Takenoyama M, Yasumoto K, Kimura G, Nomoto K.
  Systemic administration of interleukin-12 can restore the anti-tumor potential of B16 melanoma-draining lymph node cells impaired at a late tumor-bearing state. Int. J. Cancer. 1998 Jan;75(3):400-405.
• Abe K, Harada M, Tamada K, Ito O, Li T, Nomoto K.
  Early-appearing tumor-infiltrating natural killer cells play an important role in the nitric oxide production of tumor-associated macrophages through their interferon production. Cancer Immunol. Immunother. 1998 Jan;45(5):225-233.
• Li T, Harada M, Tamada K, Abe K, Nomoto K.
  Repeated restraint stress impairs the antitumor T cell response through its suppressive effect on Th1-type CD4+ T cells. Anticancer Research. 1997 Nov-Dec;17(6D):4259-4268.
• Tamada K, Harada M, Abe K, Li T, Tada H, Onoe Y, Nomoto K.
  (corresponding author) Immunosuppressive activity of cloned NK1.1+ T cells established from murine tumor-infiltrating lymphocytes. J. Immunol. 1997 May;158(10):4846-4854.
• Okamoto T, Harada M, Tamada K, Yoshida H, Ito O, Kong YY, Takenoyama M, Hirashima C, Matsuzaki G, Nomoto K.
  Local injections of OK432 can augment the TH1-type T-cell response in tumor-draining lymph node cells and increase their immunotherapeutical potential. Int. J. Cancer. 1997 Mar;70(5):598-605.
• Shinomiya Y, Harada M, Tamada K, Kurosawa S, Okamoto T, Terao H, Takenoyama M, Ito O, Hirashima C, Li T, Shirakusa T, Nomoto K.
  The augmenting effect of OK432-stimulated B cells on the in vitro generation of anti-tumor cytotoxic T lymphocytes from tumor-draining lymph node cells: The possible role of interleukin-12. In vivo. 1997 Jan-Feb;11(1):1-8.
• Harada M, Matsunaga K, Oguchi Y, Iijima H, Tamada K, Abe K, Takenoyama M, Ito O, Kimura G, Nomoto K.
  Oral administration of PSK can improve the impaired anti-tumor CD4+ T cell response in gut-associated lymphoid tissue (GALT) of specific-pathogen-free mice. Int. J. Cancer. 1997 Jan;70(3):362-372.
• Tamada K, Harada M, Ito O, Takenoyama M, Mori T, Matsuzaki G, Nomoto K.
  The emergence of non-cytolytic NK1.1+ T cells in the long-term culture of murine tumor-infiltrating lymphocytes: A possible role of transforming growth factor-β. Immunology. 1996 Dec;89(4):627-635.
• Li T, Harada M, Tamada K, Abe K, Ito O, Takenoyama M, Nomoto K.
  The antitumor effect induced by local injections with interleukin-2 is diminished by combining with a local injection with mitomycin C. Immunopharmac. Immunotoxicol. 1996 Nov;18(4):497-509.
• Harada M, Sumichika H, Hamano S, Ito O, Tamada K, Takenoyama M, Kimura G, Nomoto K.
  IL-3 derived from CD4+ T cells is essential for the in vitro expansion of mast cells from the normal adult mouse spleen. Clin. Exp. Immunol. 1996 Oct;106(1):149-155.
• Terao H, Harada M, Kurosawa S, Shinomiya Y, Ito O, Tamada K, Takenoyama M, Nomoto K.
  The opposite effect of tumor-infiltrating natural killer cells on in vivo priming between tumor-specific CD8+ and CD4+ T cells. Immunobiology. 1996 Jul;195(2):172-186.
• Harada M, Okamoto T, Omoto K, Tamada K, Takenoyama M, Hirashima C, Ito O, Kimura G, Nomoto K.
  Specific immunotherapy with tumor-draining lymph node cells cultured with both anti-CD3 and anti-CD28 monoclonal antibodies. Immunology. 1996 Mar; 87(3):447–453.
• Tamada K, Harada M, Okamoto T, Takenoyama M, Ito O, Matsuzaki G, Nomoto K.
  Specific antitumor activity of tumor-infiltrating lymphocytes expanded first in a culture with both anti-CD3 monoclonal antibody and activated B cells and then in a culture with interleukin-2. Cancer Immunol. Immunother. 1995 Dec;41(6):339-347.
• Harada M, Matsunaga K, Oguchi Y, Iijima H, Ito O, Tamada K, Kimura G, Nomoto K.
  The involvement of transforming growth factor beta in the impaired antitumor T-cell response at the gut-associated lymphoid tissue (GALT). Cancer Res. 1995 Dec;55(24):6146-6151.
• Harada M, Seta K, Ito O, Tamada K, Li T, Terao H, Takenoyama M, Kimura G, Nomoto K.
  Concomitant immunity against tumor development is enhanced by the oral administration of a kampo medicine, Hochu-ekki-to. Immunopharmac. Immunotoxicol. 1995 Nov;17(4):687-703.

准教授佐古田　幸美

1. Sasaki T, Sakoda Y, Adachi K, Tokunaga Y, Tamada K.
   Therapeutic effects of anti-GM2 CAR-T cells expressing IL-7 and CCL19 for GM2-positive solid cancer in xenograft model. Cancer Med., 2023 Jun;12(11):12569-12580. doi: 10.1002/cam4.5907. Epub 2023 Apr 9.
2. Ohta K, Sakoda Y, Tamada K.
   Novel technologies for improving the safety and efficacy of CAR-T cell therapy, Int J Hematol. 2023 May;117(5):647-651. Epub 2022 Oct 29.
3. Tokunaga Y, Sasaki T, Goto S, Adachi K, Sakoda Y, Tamada K.
   Enhanced anti-tumor responses of tumor antigen-specific TCR-T cells genetically engineered to produce IL-7 and CCL19, Mol Cancer Ther. 2022 Jan;21(1):138-148.
4. Goto S, Sakoda Y, Adachi K, Sekido Y, Yano S, Eto M, Tamada K.
   Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models. Cancer Immunol Immunother. 2021 Sep;70(9):2503-2515. Epub 2021 Feb
5. Mori J, Adachi K, Sakoda Y, Sasaki T, Goto S, Matsumoto H, Nagashima Y, Matsuyama H, Tamada K.
   Anti-tumor efficacy of human anti-c-met CAR-T cells against papillary renal cell carcinoma in an orthotopic model. Cancer Sci. 2021 Apr;112(4):1417-1428.
6. Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K.
   Improved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells. Cancer Science. 2019 Oct;110(10):3079-3088.
7. Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
   Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment. Cancer Immunol Immunother. 2019 Feb;68(2):201-211.
8. Keishi Adachi, Yosuke Kano, Tomohiko Nagai, Namiko Okuyama, Yukimi Sakoda, Koji Tamada.
   IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol., 2018 Apr;36(4):346-351.
9. 18. Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K.
   Combined adjuvants of poly(I:C) plus LAG-3-Ig improve anti-tumor effects of tumor-specific T cells preventing their exhaustion. Cancer Sci. 2016 Apr;107(4):398-406.
10. Sakoda Y, Nagai T, Murata S, Mizuno Y, Kurosawa H, Shoda H, Morishige N, Yanai R, Sonoda KH, Tamada K.
    Pathogenic Function of Herpesvirus Entry Mediator in Experimental Autoimmune Uveitis by Induction of Th1- and Th17-Type T Cell Responses. J Immunol. 2016 Apr;196(7):2947-2954.
11. Shoda H, Yanai R, Yoshimura T, Nagai T, Kimura K, Sobrin L, Connor KM, Sakoda Y, Tamada K, Ikeda T, Sonoda KH.
    Dietary Omega-3 Fatty Acids Suppress Experimental Autoimmune Uveitis in Association with Inhibition of Th1 and Th17 Cell Function. PLoS One, 2015 Sep;10(9):e0138241.
12. Cairo C, Surendran N, Harris KM, Mazan-Mamczarz K, Sakoda Y, Diaz-Mendez F, Tamada K, Gartenhaus RB, Mann DL, Pauza CD.
    Vγ2Vδ2 T cell Costimulation Increases NK cell Killing of Monocyte-derived Dendritic Cells. Immunology. 2014 Sep;144(3):422-430.
13. Sakoda Y, Tamada K.
    Development of cancer immunotherapy by next generation multi-targeting CAR-T cells. Rinsho Ketsueki. 2014 Jun;55(6):651-656.
14. Tamada K, Geng D, Sakoda Y, Bansal N, Srivastava R, Davila E.
    Redirecting gene-modified T cells toward various cancer types using tagged antibodies. Clin. Cancer Res. 2012 Dec;18(23):6436-6445.
15. Jain A, Olsen HS, Vyzasatya R, Burch E, Sakoda Y, Merigeon EY, Cai L, Lu C, Tan M, Tamada K, Schulze D, Block DS, Strome SE.
    Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice. Arthritis Res. Ther. 2012 Aug;14(4):R192.
16. Park JJ, Anand S, Zhao Y, Matsumura Y, Sakoda Y, Kuramasu A, Strome SE, Chen L, Tamada K.
    Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory. Cancer Immunol Immunother. 2012 Feb;61(2):203-214.
17. Sakoda Y, Anand S, Zhao Y, Park JJ, Liu Y, Kuramasu A, Rooijen NV, Chen L, Strome SE, Hancock WW, Chen L, Tamada K.
    Herpesvirus Entry Mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J. Clin. Invest. 2011, Dec;121(12):4810-4819
18. Sakoda Y, Park JJ, Zhao Y, Kuramasu A, Geng D, Liu Y, Davila E, Tamada K.
    Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway. Blood. 2011 Feb;117(8):2506-2514.
19. Kim YS, Park JJ, Sakoda Y, Zhao Y, Hisamichi K, Kaku T, Tamada K.
    Preventive and therapeutic potential of placental extract in contact hypersensitivity. Int Immunopharmacol. 2010 Oct;10(10):1177-1184.
20. Park JJ, Omiya R, Matsumura Y, Sakoda Y, Kuramasu A, Augustine MM, Yao S, Tsushima F, Narazaki H, Anand S, Liu Y, Strome SE, Chen L, Tamada K.
    B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood. 2010 Aug 26;116(8):1291-1298.
21. Omiya R, Tsushima F, Narazaki H, Sakoda Y, Kuramasu A, Kim Y, Xu H, Tamura H, Zhu G, Chen L, Tamada K.
    Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity. Immunology. 2009 Dec;128(4):543-555.
22. Hashimoto D, Asakura S, Matsuoka K, Sakoda Y, Koyama M, Aoyama K, Tanimoto M, Teshima T.
    FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease. Eur J Immunol. 2007 Jan;37(1):271-281.
23. Sakoda Y, Hashimoto D, Asakura S, Takeuchi K, Harada M, Tanimoto M, Teshima T.
    Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease. Blood. 2007 Feb;109(4):1756-1764.

　　

講師安達　圭志

1. Sasaki T, Sakoda Y, Adachi K, Tokunaga Y, Tamada K.
   Therapeutic effects of anti-GM2 CAR-T cells expressing IL-7 and CCL19 for GM2-positive solid cancer in xenograft model. Cancer Med., 2023 Jun;12(11):12569-12580. doi: 10.1002/cam4.5907. Epub 2023 Apr 9.
2. Adachi K, Tamada K.
   Paving the road to make chimeric antigen receptor-Tcell therapy effective against solid tumors, Cancer Sci, 2022 Dec;113(12):4020-4029.
3. Tokunaga Y, Sasaki T, Goto S, Adachi K, Sakoda Y, Tamada K.
   Enhanced anti-tumor responses of tumor antigen-specific TCR-T cells genetically engineered to produce IL-7 and CCL19, Mol Cancer Ther. 2022 Jan;21(1):138-148.
4. Goto S, Sakoda Y, Adachi K, Sekido Y, Yano S, Eto M, Tamada K.
   Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models. Cancer Immunol Immunother. 2021 Sep;70(9):2503-2515. Epub 2021 Feb.
5. Mori J, Adachi K, Sakoda Y, Sasaki T, Goto S, Matsumoto H, Nagashima Y, Matsuyama H, Tamada K.
   Anti-tumor efficacy of human anti-c-met CAR-T cells against papillary renal cell carcinoma in an orthotopic model. Cancer Sci. 2021 Apr;112(4):1417-1428.
6. Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K.
   Improved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells. Cancer Science. 2019 Oct;110(10):3079-3088.
7. Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
   Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment. Cancer Immunol Immunother. 2019 Feb;68(2):201-211
8. Adachi K, Tamada K.
   Microbial biomarkers for immune checkpoint blockade therapy against cancer. J Gastroenterol. 2018 Sep; 53(9):999–1005.
9. 14. Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K.
   IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol. 2018 Apr;36(4):346-351.
10. Chadeka EA, Nagi S, Sunahara T, Cheruiyot NB, Bahati F, Ozeki Y, Inoue M, Osada-Oka M, Okabe M, Hirayama Y, Changoma M, Adachi K, Mwende F, Kikuchi M, Nakamura R, Kalenda YDJ, Kaneko S, Hirayama K, Shimada M, Ichinose Y, Njenga SM, Matsumoto S, Hamano S
    Spatial Distribution and Risk Factors of Schistosoma haematobium and Hookworm Infections among Schoolchildren in Kwale, Kenya. PLOS Neglected Tropical Diseases, 2017 Sep;11(9).
11. Deloer S, Nakamura R, Mi-Ichi F, Adachi K, Kobayashi S, Hamano S.
    Mouse models of amoebiasis and culture methods of amoeba. Parasitol Int. 2016 Oct;65(5 Pt B):520-525.
12. 18. Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K.
    Combined adjuvants of poly(I:C) plus LAG-3-Ig improve anti-tumor effects of tumor-specific T cells preventing their exhaustion. Cancer Sci. 2016 Apr;107(4):398-406.
13. Adachi K, Tamada K.
    Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy. Cancer Sci. 2015 Aug;106(8):945-50.
14. Yu W, Jiang N, Ebert PJ, Kidd BA, Müller S, Lund PJ, Juang J, Adachi K, Tse T, Birnbaum ME, Newell EW, Wilson DM, Grotenbreg GM, Valitutti S, Quake SR, Davis MM.
    Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes. Immunity. 2015 May;42(5):929-41.
15. Miyake K*, Adachi K*, Watanabe M, Sasatomi Y, Ogahara S, Abe Y, Ito K, Dan Jusutin YK, Saito T, Nakashima H, and Hamano S.
    Parasites alter the pathological phenotype of lupus nephritis. Antoimmunity. 2014 Dec;47(8):538-47.
    *These authors contributed equally to this work
16. Adachi K, Nakamura R, Osada Y, Senba M, Tamada K, Hamano S.
    Involvement of IL-18 in the Expansion of Unique Hepatic T Cells with Unconventional Cytokine Profiles during Schistosoma mansoni Infection. PLoS ONE. 2017 Sep;11(9):e0005872
17. Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S.
    Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection. PLoS One. 2013 Dec;8(12):e82698.
18. Adachi K and Davis MM.
    TCR ligation induces distinct signaling pathways in naïve versus antigen-experienced T cells Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1549-54
19. Kyo F, Futani H, Matsui K, Terada M, Adachi K, Nagata K, Sano H, Tateishi H, Tsutsui H and Nakanishi K.
    Endogenous IL-6 but not TNF-α contributes to the development of TLR4/MyD88-mediated acute arthritis in mice.Arthritis Rheum. 2005 Aug;52(8):2530-40.
20. Fujii H, Seki S, Kobayashi S, Kitada T, Kawakita N, Adachi K, Tsutsui H, Nakanishi K, Fujiwara H, Ikarashi Y, Taniguchi M, Mitchell K, Ikemoto M, Nakajima Y, Arakawa T and Kaneda K.
    A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/ D-galactosamine.Virchows Arch. 2005 Jun;446(6):663-73
21. Ohmori T, Adachi K, Fukuda Y, Tamahara S, Matsuki N, Ono K.
    Glucose uptake activity in murine red blood cells infected with Babesia microti and Babesia rodhaini. J Vet Med Sci. 2004 Aug;66(8):945-9.
22. Adachi K, Tsutsui H, Seki E, Nakano H, Takeda K, Okumura K, Van Kaer L,Nakanishi K.
    Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int Immunol. 2004 Jun;16(6):787-98.
23. Tsutsui H, Adachi K, Seki E, Nakanishi K.
    Cytokine-induced inflammatory liver injuries. Curr Mol Med. 2003 Sep;3(6):545-59.
24. Seki E, Tsutsui H, Tsuji NM, Hayashi N, Adachi K, Nakano H, Futatsugi-Yumikura S, Takeuchi O, Hoshino K, Akira S, Fujimoto J, Nakanishi K.
    Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol. 2002 Oct;169(7):3863-8.
25. Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K.
    Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol. 2001 Nov;167(10):5928-34.
26. Naka T, Tsutsui H, Fujimoto M, Kawazoe Y, Kohzaki H, Morita Y, Nakagawa R, Narazaki M, Adachi K, Yoshimoto T, Nakanishi K, Kishimoto T.
    SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo. Immunity. 2001 May;14(5):535-45.
27. Seki E, Tsutsui H, Nakano H, Tsuji N, Hoshino K, Adachi O, Adachi K, Futatsugi S, Kuida K, Takeuchi O, Okamura H, Fujimoto J, Akira S, Nakanishi K.
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助教城﨑　幸介

1. Tamura I, Maekawa R, Jozaki K, Ohkawa Y, Takagi H, Doi-Tanaka Y, Shirafuta Y, Mihara Y, Taketani T, Sato S, Tamura H, Sugino N.
   Transcription factor C/EBPβ induces genome-wide H3K27ac and upregulates gene expression during decidualization of human endometrial stromal cells. Mol Cell Endocrinol. 2021 Jan;15;520:111085.
2. Jozaki K, Tamura I, Takagi H, Shirafuta Y, Mihara Y, Shinagawa M, Maekawa R, Taketani T, Asada H, Sato S, Tamura H, Sugino N.
   Glucose Regulates the Histone Acetylation of Gene Promoters in Decidualizing Stromal Cells.2019 May;157(5):457-464.
3. Tamura I, Shirafuta Y, Jozaki K, Kajimura T, Shinagawa M, Maekawa R, Taketani T, Asada H, Sato S, Tamura H, Sugino N.
   Novel function of a transcription factor WT1 in regulating decidualization in human endometrial stromal cells and its molecular mechanism. Endocrinology, 2017 Oct;158(10):3696-3707.
4. Maekawa R, Taketani T, Mihara Y, Sato S, Okada M, Tamura I, Jozaki K, Kajimura T, Asada H, Tamura H, Takasaki A, Sugino N.
   Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure. Reprod Med Biol, 2017 Apr;16(2):206-227
5. Sugino N, Tamura I, Maekawa R, Jozaki K. Uterine Endometrial Function, edited by Kanzaki H,
   Decidualization and epigenetic regulation. Springer, 2016. p125-137.
6. Sato S, Maekawa R, Yamagata Y, Tamura I, Lee L, Okada M, Jozaki K, Asada H, Tamura H. Sugino N.
   Identification of uterine leiomyoma-specific marker genes based on DNA methylation and their clinical application. Sci Rep. 2016 Aug 8;6:30652.
7. Ohtsuka Y, Higashimoto K, Oka T, Yatsuki H, Jozaki K, Maeda T, Kawahara K, Hamasaki Y, Matsuo M, Nishioka K, Joh K, Mukai T, Soejima H.
   Identification of consensus motifs associated with mitotic recombination and clinical characteristics in patients with paternal uniparental isodisomy of chromosome 11. Hum Mol Genet. 2016 Apr;25(7):1406-19.
8. Maekawa R, Sato S, Okada M, Lee L, Tamura I, Jozaki K, Kajimura T, Asada H, Yamagata Y, Tamura H, Yamamoto S, Sugino N.
   Tissue-Specific Expression of Estrogen Receptor 1 Is Regulated by DNA Methylation in a T-DMR. Mol Endocrinol. 2016 Mar;30(3):335-47.
9. Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, Sato S, Maekawa R, Taketani T,Asada H, Tamura H, Nakai A, Sugino N.
   Retinoic acid has the potential to suppress endometriosis development. J Ovarian Res. 2015 Jul;31;8:49.
10. Takama Y, Kubota A, Nakayama M, Higashimoto K, Jozaki K, Soejima H.
    Fibroadenoma in Beckwith-Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5. Pediatr Int. 2014 Dec;56(6):931-934.
11. Tamura I, Ohkawa Y, Sato T, Suyama M, Jozaki K, Okada M, Lee L, Maekawa R, Asada H, Sato S, Yamagata Y, Tamura H, Sugino N.
    Genome-wide analysis of histone modifications in human endometrial stromal cells. Mol Endocrinol. 2014 Oct;28(10):1656-69.
12. Maeda T, Higashimoto K, Jozaki K, Yatsuki H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H.
    Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations. Genet Med. 2014 Dec;16(12):903-12.
13. Higashimoto Ken, Nakabayashi Kazuhiko, Yatsuki Hitomi, Yoshinaga Hokuto, Jozaki K, Okada Junichiro, Watanabe Yoriko, Aoki Aiko, Shiozaki Arihiro, Saito Shigeru, Koide Kayoko, Mukai Tsunehiro, Hata Kenichiro & Soejima Hidenobu.
    Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome. American Journal of Medical Genetics. 2012 Jul;158A(7):1670-5.
14. Uenishi Hirohide, Shinkai Hiroki, Morozumi Takeya, Muneta Yoshihiro, Jozaki K, Kojima-Shibata Chihiro, Suzuki Eisaku.
    Polymorphisms in pattern recognition receptors and their relationship to infectious disease susceptibility in pigs. BMC Proceedings. 2011 Jun;5 Suppl 4:S27.
15. Jozaki K, Shinkai Hiroki, Morozumi Takeya, Tanaka-Matsuda Maiko, Eguchi-Ogawa Tomoko, Wada Yasuhiko, Uenishi Hirohide.
    Cloning, expression, and polymorphisms of natural killer cell receptor NCR1 in pigs. Animal Biotechnology. 2010 Jul;21(3):156-63.
16. Jozaki K, Shinkai Hiroki, Tanaka-Matsuda Maiko, Morozumi Takeya, Matsumoto Toshimi, Toki Daisuke, Okumura Naohiko, Eguchi-Ogawa Tomoko, Kojima-Shibata Chihiro, Kadowaki Hiroshi, Suzuki Eisaku, Wada Yasuhiko, Uenishi Hirohide.
    Influence of polymorphisms in porcine NOD2 on ligand recognition. Molecular Immunology. 2009 Dec;47(2-3):247-52.
17. Kojima-Shibata Chihiro, Shinkai Hiroki, Morozumi Takeya, Jozaki K, Toki Daisuke, Matsumoto Toshimi, Kadowaki Hiroshi, Suzuki Eisaku, Uenishi Hirohide.
    Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs. Immunogenetics. 2009 Feb;61(2):153-60.

Copyright 2011 by Yamaguchi University Graduate School of Medicine, Department of Immunology