業績

教授
玉田 耕治
准教授
佐古田 幸美
講師
安達 圭志
助教
城﨑 幸介

教授玉田 耕治

2021
2020
2019
2018
2017
2016
2015
2014
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
2000年以前の主な業績

准教授佐古田 幸美

  1. Tokunaga Y, Sasaki T, Goto S, Adachi K, Sakoda Y, Tamada K.
    Enhanced anti-tumor responses of tumor antigen-specific TCR-T cells genetically engineered to produce IL-7 and CCL19, Mol Cancer Ther. 2021 Oct. Online ahead of print.
  2. Mori J, Adachi K, Sakoda Y, Sasaki T, Goto S, Matsumoto H, Nagashima Y, Matsuyama H, Tamada K.
    Anti-tumor efficacy of human anti-c-met CAR-T cells against papillary renal cell carcinoma in an orthotopic model. Cancer Sci. 2021 Apr;112(4):1417-1428.
  3. Goto S, Sakoda Y, Adachi K, Sekido Y, Yano S, Eto M, Tamada K.
    Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models. Cancer Immunol Immunother. 2021 Sep;70(9):2503-2515. Epub 2021 Feb
  4. Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K.
    Improved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells. Cancer Science. 2019 Oct;110(10):3079-3088.
  5. Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
    Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment. Cancer Immunol Immunother. 2019 Feb;68(2):201-211.
  6. Keishi Adachi, Yosuke Kano, Tomohiko Nagai, Namiko Okuyama, Yukimi Sakoda, Koji Tamada.
    IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol., 2018 Apr;36(4):346-351.
  7. 18. Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K.
    Combined adjuvants of poly(I:C) plus LAG-3-Ig improve anti-tumor effects of tumor-specific T cells preventing their exhaustion. Cancer Sci. 2016 Apr;107(4):398-406.
  8. Sakoda Y, Nagai T, Murata S, Mizuno Y, Kurosawa H, Shoda H, Morishige N, Yanai R, Sonoda KH, Tamada K.
    Pathogenic Function of Herpesvirus Entry Mediator in Experimental Autoimmune Uveitis by Induction of Th1- and Th17-Type T Cell Responses. J Immunol. 2016 Apr;196(7):2947-2954.
  9. Shoda H, Yanai R, Yoshimura T, Nagai T, Kimura K, Sobrin L, Connor KM, Sakoda Y, Tamada K, Ikeda T, Sonoda KH.
    Dietary Omega-3 Fatty Acids Suppress Experimental Autoimmune Uveitis in Association with Inhibition of Th1 and Th17 Cell Function. PLoS One, 2015 Sep;10(9):e0138241.
  10. Cairo C, Surendran N, Harris KM, Mazan-Mamczarz K, Sakoda Y, Diaz-Mendez F, Tamada K, Gartenhaus RB, Mann DL, Pauza CD.
    Vγ2Vδ2 T cell Costimulation Increases NK cell Killing of Monocyte-derived Dendritic Cells. Immunology. 2014 Sep;144(3):422-430.
  11. Sakoda Y, Tamada K.
    Development of cancer immunotherapy by next generation multi-targeting CAR-T cells. Rinsho Ketsueki. 2014 Jun;55(6):651-656.
  12. Tamada K, Geng D, Sakoda Y, Bansal N, Srivastava R, Davila E.
    Redirecting gene-modified T cells toward various cancer types using tagged antibodies. Clin. Cancer Res. 2012 Dec;18(23):6436-6445.
  13. Jain A, Olsen HS, Vyzasatya R, Burch E, Sakoda Y, Merigeon EY, Cai L, Lu C, Tan M, Tamada K, Schulze D, Block DS, Strome SE.
    Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice. Arthritis Res. Ther. 2012 Aug;14(4):R192.
  14. Park JJ, Anand S, Zhao Y, Matsumura Y, Sakoda Y, Kuramasu A, Strome SE, Chen L, Tamada K.
    Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory. Cancer Immunol Immunother. 2012 Feb;61(2):203-214.
  15. Sakoda Y, Anand S, Zhao Y, Park JJ, Liu Y, Kuramasu A, Rooijen NV, Chen L, Strome SE, Hancock WW, Chen L, Tamada K.
    Herpesvirus Entry Mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J. Clin. Invest. 2011, Dec;121(12):4810-4819
  16. Sakoda Y, Park JJ, Zhao Y, Kuramasu A, Geng D, Liu Y, Davila E, Tamada K.
    Dichotomous regulation of GVHD through bidirectional functions of the BTLA-HVEM pathway. Blood. 2011 Feb;117(8):2506-2514.
  17. Kim YS, Park JJ, Sakoda Y, Zhao Y, Hisamichi K, Kaku T, Tamada K.
    Preventive and therapeutic potential of placental extract in contact hypersensitivity. Int Immunopharmacol. 2010 Oct;10(10):1177-1184.
  18. Park JJ, Omiya R, Matsumura Y, Sakoda Y, Kuramasu A, Augustine MM, Yao S, Tsushima F, Narazaki H, Anand S, Liu Y, Strome SE, Chen L, Tamada K.
    B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood. 2010 Aug 26;116(8):1291-1298.
  19. Omiya R, Tsushima F, Narazaki H, Sakoda Y, Kuramasu A, Kim Y, Xu H, Tamura H, Zhu G, Chen L, Tamada K.
    Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity. Immunology. 2009 Dec;128(4):543-555.
  20. Hashimoto D, Asakura S, Matsuoka K, Sakoda Y, Koyama M, Aoyama K, Tanimoto M, Teshima T.
    FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease. Eur J Immunol. 2007 Jan;37(1):271-281.
  21. Sakoda Y, Hashimoto D, Asakura S, Takeuchi K, Harada M, Tanimoto M, Teshima T.
    Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease. Blood. 2007 Feb;109(4):1756-1764.
  

講師安達 圭志

  1. Tokunaga Y, Sasaki T, Goto S, Adachi K, Sakoda Y, Tamada K.
    Enhanced anti-tumor responses of tumor antigen-specific TCR-T cells genetically engineered to produce IL-7 and CCL19, Mol Cancer Ther. 2021 Oct. Online ahead of print.
  2. Mori J, Adachi K, Sakoda Y, Sasaki T, Goto S, Matsumoto H, Nagashima Y, Matsuyama H, Tamada K.
    Anti-tumor efficacy of human anti-c-met CAR-T cells against papillary renal cell carcinoma in an orthotopic model. Cancer Sci. 2021 Apr;112(4):1417-1428.
  3. Goto S, Sakoda Y, Adachi K, Sekido Y, Yano S, Eto M, Tamada K.
    Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models. Cancer Immunol Immunother. 2021 Sep;70(9):2503-2515. Epub 2021 Feb.
  4. Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K.
    Improved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells. Cancer Science. 2019 Oct;110(10):3079-3088.
  5. Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
    Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment. Cancer Immunol Immunother. 2019 Feb;68(2):201-211
  6. Adachi K, Tamada K.
    Microbial biomarkers for immune checkpoint blockade therapy against cancer. J Gastroenterol. 2018 Sep; 53(9):999–1005.
  7. 14. Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K.
    IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol. 2018 Apr;36(4):346-351.
  8. Chadeka EA, Nagi S, Sunahara T, Cheruiyot NB, Bahati F, Ozeki Y, Inoue M, Osada-Oka M, Okabe M, Hirayama Y, Changoma M, Adachi K, Mwende F, Kikuchi M, Nakamura R, Kalenda YDJ, Kaneko S, Hirayama K, Shimada M, Ichinose Y, Njenga SM, Matsumoto S, Hamano S
    Spatial Distribution and Risk Factors of Schistosoma haematobium and Hookworm Infections among Schoolchildren in Kwale, Kenya. PLOS Neglected Tropical Diseases, 2017 Sep;11(9).
  9. Deloer S, Nakamura R, Mi-Ichi F, Adachi K, Kobayashi S, Hamano S.
    Mouse models of amoebiasis and culture methods of amoeba. Parasitol Int. 2016 Oct;65(5 Pt B):520-525.
  10. 18. Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K.
    Combined adjuvants of poly(I:C) plus LAG-3-Ig improve anti-tumor effects of tumor-specific T cells preventing their exhaustion. Cancer Sci. 2016 Apr;107(4):398-406.
  11. Adachi K, Tamada K.
    Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy. Cancer Sci. 2015 Aug;106(8):945-50.
  12. Yu W, Jiang N, Ebert PJ, Kidd BA, Müller S, Lund PJ, Juang J, Adachi K, Tse T, Birnbaum ME, Newell EW, Wilson DM, Grotenbreg GM, Valitutti S, Quake SR, Davis MM.
    Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes. Immunity. 2015 May;42(5):929-41.
  13. Miyake K*, Adachi K*, Watanabe M, Sasatomi Y, Ogahara S, Abe Y, Ito K, Dan Jusutin YK, Saito T, Nakashima H, and Hamano S.
    Parasites alter the pathological phenotype of lupus nephritis. Antoimmunity. 2014 Dec;47(8):538-47.
    *These authors contributed equally to this work
  14. Adachi K, Nakamura R, Osada Y, Senba M, Tamada K, Hamano S.
    Involvement of IL-18 in the Expansion of Unique Hepatic T Cells with Unconventional Cytokine Profiles during Schistosoma mansoni Infection. PLoS ONE. 2017 Sep;11(9):e0005872
  15. Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S.
    Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection. PLoS One. 2013 Dec;8(12):e82698.
  16. Adachi K and Davis MM.
    TCR ligation induces distinct signaling pathways in naïve versus antigen-experienced T cells Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1549-54
  17. Kyo F, Futani H, Matsui K, Terada M, Adachi K, Nagata K, Sano H, Tateishi H, Tsutsui H and Nakanishi K.
    Endogenous IL-6 but not TNF-α contributes to the development of TLR4/MyD88-mediated acute arthritis in mice.Arthritis Rheum. 2005 Aug;52(8):2530-40.
  18. Fujii H, Seki S, Kobayashi S, Kitada T, Kawakita N, Adachi K, Tsutsui H, Nakanishi K, Fujiwara H, Ikarashi Y, Taniguchi M, Mitchell K, Ikemoto M, Nakajima Y, Arakawa T and Kaneda K.
    A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/ D-galactosamine.Virchows Arch. 2005 Jun;446(6):663-73
  19. Ohmori T, Adachi K, Fukuda Y, Tamahara S, Matsuki N, Ono K.
    Glucose uptake activity in murine red blood cells infected with Babesia microti and Babesia rodhaini. J Vet Med Sci. 2004 Aug;66(8):945-9.
  20. Adachi K, Tsutsui H, Seki E, Nakano H, Takeda K, Okumura K, Van Kaer L,Nakanishi K.
    Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int Immunol. 2004 Jun;16(6):787-98.
  21. Tsutsui H, Adachi K, Seki E, Nakanishi K.
    Cytokine-induced inflammatory liver injuries. Curr Mol Med. 2003 Sep;3(6):545-59.
  22. Seki E, Tsutsui H, Tsuji NM, Hayashi N, Adachi K, Nakano H, Futatsugi-Yumikura S, Takeuchi O, Hoshino K, Akira S, Fujimoto J, Nakanishi K.
    Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol. 2002 Oct;169(7):3863-8.
  23. Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K.
    Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol. 2001 Nov;167(10):5928-34.
  24. Naka T, Tsutsui H, Fujimoto M, Kawazoe Y, Kohzaki H, Morita Y, Nakagawa R, Narazaki M, Adachi K, Yoshimoto T, Nakanishi K, Kishimoto T.
    SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo. Immunity. 2001 May;14(5):535-45.
  25. Seki E, Tsutsui H, Nakano H, Tsuji N, Hoshino K, Adachi O, Adachi K, Futatsugi S, Kuida K, Takeuchi O, Okamura H, Fujimoto J, Akira S, Nakanishi K.
    Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β. J Immunol. 2001 Feb;166(4):2651-7.

助教城﨑 幸介

  1. Tamura I, Maekawa R, Jozaki K, Ohkawa Y, Takagi H, Doi-Tanaka Y, Shirafuta Y, Mihara Y, Taketani T, Sato S, Tamura H, Sugino N.
    Transcription factor C/EBPβ induces genome-wide H3K27ac and upregulates gene expression during decidualization of human endometrial stromal cells. Mol Cell Endocrinol. 2021 Jan;15;520:111085.
  2. Jozaki K, Tamura I, Takagi H, Shirafuta Y, Mihara Y, Shinagawa M, Maekawa R, Taketani T, Asada H, Sato S, Tamura H, Sugino N.
    Glucose Regulates the Histone Acetylation of Gene Promoters in Decidualizing Stromal Cells.2019 May;157(5):457-464.
  3. Tamura I, Shirafuta Y, Jozaki K, Kajimura T, Shinagawa M, Maekawa R, Taketani T, Asada H, Sato S, Tamura H, Sugino N.
    Novel function of a transcription factor WT1 in regulating decidualization in human endometrial stromal cells and its molecular mechanism. Endocrinology, 2017 Oct;158(10):3696-3707.
  4. Maekawa R, Taketani T, Mihara Y, Sato S, Okada M, Tamura I, Jozaki K, Kajimura T, Asada H, Tamura H, Takasaki A, Sugino N.
    Thin endometrium transcriptome analysis reveals a potential mechanism of implantation failure. Reprod Med Biol, 2017 Apr;16(2):206-227
  5. Sugino N, Tamura I, Maekawa R, Jozaki K. Uterine Endometrial Function, edited by Kanzaki H,
    Decidualization and epigenetic regulation. Springer, 2016. p125-137.
  6. Sato S, Maekawa R, Yamagata Y, Tamura I, Lee L, Okada M, Jozaki K, Asada H, Tamura H. Sugino N.
    Identification of uterine leiomyoma-specific marker genes based on DNA methylation and their clinical application. Sci Rep. 2016 Aug 8;6:30652.
  7. Ohtsuka Y, Higashimoto K, Oka T, Yatsuki H, Jozaki K, Maeda T, Kawahara K, Hamasaki Y, Matsuo M, Nishioka K, Joh K, Mukai T, Soejima H.
    Identification of consensus motifs associated with mitotic recombination and clinical characteristics in patients with paternal uniparental isodisomy of chromosome 11. Hum Mol Genet. 2016 Apr;25(7):1406-19.
  8. Maekawa R, Sato S, Okada M, Lee L, Tamura I, Jozaki K, Kajimura T, Asada H, Yamagata Y, Tamura H, Yamamoto S, Sugino N.
    Tissue-Specific Expression of Estrogen Receptor 1 Is Regulated by DNA Methylation in a T-DMR. Mol Endocrinol. 2016 Mar;30(3):335-47.
  9. Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, Sato S, Maekawa R, Taketani T,Asada H, Tamura H, Nakai A, Sugino N.
    Retinoic acid has the potential to suppress endometriosis development. J Ovarian Res. 2015 Jul;31;8:49.
  10. Takama Y, Kubota A, Nakayama M, Higashimoto K, Jozaki K, Soejima H.
    Fibroadenoma in Beckwith-Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5. Pediatr Int. 2014 Dec;56(6):931-934.
  11. Tamura I, Ohkawa Y, Sato T, Suyama M, Jozaki K, Okada M, Lee L, Maekawa R, Asada H, Sato S, Yamagata Y, Tamura H, Sugino N.
    Genome-wide analysis of histone modifications in human endometrial stromal cells. Mol Endocrinol. 2014 Oct;28(10):1656-69.
  12. Maeda T, Higashimoto K, Jozaki K, Yatsuki H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H.
    Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations. Genet Med. 2014 Dec;16(12):903-12.
  13. Higashimoto Ken, Nakabayashi Kazuhiko, Yatsuki Hitomi, Yoshinaga Hokuto, Jozaki K, Okada Junichiro, Watanabe Yoriko, Aoki Aiko, Shiozaki Arihiro, Saito Shigeru, Koide Kayoko, Mukai Tsunehiro, Hata Kenichiro & Soejima Hidenobu.
    Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome. American Journal of Medical Genetics. 2012 Jul;158A(7):1670-5.
  14. Uenishi Hirohide, Shinkai Hiroki, Morozumi Takeya, Muneta Yoshihiro, Jozaki K, Kojima-Shibata Chihiro, Suzuki Eisaku.
    Polymorphisms in pattern recognition receptors and their relationship to infectious disease susceptibility in pigs. BMC Proceedings. 2011 Jun;5 Suppl 4:S27.
  15. Jozaki K, Shinkai Hiroki, Morozumi Takeya, Tanaka-Matsuda Maiko, Eguchi-Ogawa Tomoko, Wada Yasuhiko, Uenishi Hirohide.
    Cloning, expression, and polymorphisms of natural killer cell receptor NCR1 in pigs. Animal Biotechnology. 2010 Jul;21(3):156-63.
  16. Jozaki K, Shinkai Hiroki, Tanaka-Matsuda Maiko, Morozumi Takeya, Matsumoto Toshimi, Toki Daisuke, Okumura Naohiko, Eguchi-Ogawa Tomoko, Kojima-Shibata Chihiro, Kadowaki Hiroshi, Suzuki Eisaku, Wada Yasuhiko, Uenishi Hirohide.
    Influence of polymorphisms in porcine NOD2 on ligand recognition. Molecular Immunology. 2009 Dec;47(2-3):247-52.
  17. Kojima-Shibata Chihiro, Shinkai Hiroki, Morozumi Takeya, Jozaki K, Toki Daisuke, Matsumoto Toshimi, Kadowaki Hiroshi, Suzuki Eisaku, Uenishi Hirohide.
    Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs. Immunogenetics. 2009 Feb;61(2):153-60.

Copyright 2011 by Yamaguchi University Graduate School of Medicine, Department of Immunology