国立大学法人 山口大学
ナノ・セラノスティクス国際センター
ー International Nano-theranostics Center ー
成果・業績
論文
2024年
【原著論文・英文】(国際共著)(産学連携)(学生参加)
Junna Nakamura, Yasuo Shiohama, Daniel Röth, Tomohiro Haruta, Yukari Yamashita, Tomohiro Mitsuzono, Chihiro Mochizuki, Markus Kalkum, Michihiro Nakamura.
Size and Surface Properties of Functionalized Organosilica Particles Impact Cell–Particle Interactions including Mitochondrial Activity.
ACS Applied Materials & Interfaces, 2024, 16, 24, 30980-30996.
( DOI:10.1021/acsami.4c06455)
【原著論文・英文】
Yasuo Shiohama, Junna Nakamura, Michihiro Nakamura.
Cellular Distribution and Intracellular Localization of Different Sizes of Fluorescent Thiol-Organosilica Particles in Mouse Lungs.
ACS Applied Materials & Interfaces, 2014, 16, 15, 18627-18642.
( DOI:10.1021/acsami.4c02051)
【原著論文・英文】(国際共著)(産学連携)(学生参加)
Junna Nakamura, Yasuo Shiohama, Daniel Röth, Tomohiro Haruta, Yukari Yamashita, Tomohiro Mitsuzono, Chihiro Mochizuki, Markus Kalkum, Michihiro Nakamura.
Size and Surface Properties of Functionalized Organosilica Particles Impact Cell–Particle Interactions including Mitochondrial Activity.
ACS Applied Materials & Interfaces, 2024, 16, 24, 30980-30996.
( DOI:10.1021/acsami.4c06455)
【原著論文・英文】
Yasuo Shiohama, Junna Nakamura, Michihiro Nakamura.
Cellular Distribution and Intracellular Localization of Different Sizes of Fluorescent Thiol-Organosilica Particles in Mouse Lungs.
ACS Applied Materials & Interfaces, 2014, 16, 15, 18627-18642.
( DOI:10.1021/acsami.4c02051)
2023年
【原著論文・英文】(学生参加)
Michihiro Nakamura, Chihiro Mochizuki, Chika Kuroda, Yasuo Shiohama, Junna Nakamura, .
Size effect of fluorescent thiol-organosilica particles on their distribution in the mouse spleen.
Colloids and Surfaces B: Biointerfaces, 2023, 228, 113397.
( DOI:10.1016/j.colsurfb.2023.113397)
【原著論文・英文】
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura.
Effects of Au States in Thiol-Organosilica Nanoparticles on Enzyme-like Activity for X-ray Sensitizer Application: Focus on Reactive Oxygen Species Generation in Radiotherapy.
ACS Omega, 2023, 8, 10, 9569–9582..
( DOI: 10.1021/acsomega.3c00096)
【原著論文・英文】(学部学生筆頭論文)
Chika Kuroda, Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura.
Size-dependent distribution of fluorescent thiol-organosilica particles in popliteal lymph nodes of mice.
OpenNano, 2023, 9, 100114.
( DOI: 10.1016/j.onano.2022.100114)
【原著論文・英文】(学生参加)
Michihiro Nakamura, Chihiro Mochizuki, Chika Kuroda, Yasuo Shiohama, Junna Nakamura, .
Size effect of fluorescent thiol-organosilica particles on their distribution in the mouse spleen.
Colloids and Surfaces B: Biointerfaces, 2023, 228, 113397.
( DOI:10.1016/j.colsurfb.2023.113397)
【原著論文・英文】
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura.
Effects of Au States in Thiol-Organosilica Nanoparticles on Enzyme-like Activity for X-ray Sensitizer Application: Focus on Reactive Oxygen Species Generation in Radiotherapy.
ACS Omega, 2023, 8, 10, 9569–9582..
( DOI: 10.1021/acsomega.3c00096)
【原著論文・英文】(学部学生筆頭論文)
Chika Kuroda, Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura.
Size-dependent distribution of fluorescent thiol-organosilica particles in popliteal lymph nodes of mice.
OpenNano, 2023, 9, 100114.
( DOI: 10.1016/j.onano.2022.100114)
【寄稿論文・和文】招待寄稿
中村 教泰
「有機シリカナノ粒子の多機能化とがん組織の蛍光イメージング」
セラミックス (CERAMICS JAPAN), 2023, 9, 580-583
公益社団法人 日本セラミックス協会
2022年
【原著論文・英文】
Chihiro Mochizuki, Juuna Nakamura, Michihiro Nakamura.
Preparation of Fetal Bovine Serum–Copper Phosphate Hybrid Particles under Cell Culture Conditions for Cancer Cell Treatment.
ACS Omega, 2022, 7, 33, 29495–29501.
( DOI: 10.1021/acsomega.2c04096)
【原著論文・英文】(国際共著)(産学連携)(学科内共著)
Michihiro Nakamura, Juuna Nakamura, Chihiro Mochizuki, Chika Kuroda, Shigeki Kato, Tomohiro Haruta, Mayu Kakefuda, Shun Sato, Fuyu Tamanoi, Norihiro Sugino.
Analysis of Cell-Nanoparticle Interactions and Imaging of In Vitro Labeled Cells Showing Barcoded Endosomes using Fluorescent Thiol-Organosilica Nanoparticles Surface-Functionalized with Polyethyleneimine.
Nanoscale Advances, 2022,.
( DOI: 10.3389/fchem.2022.907642)
【原著論文・英文】(学内他学部共著)
Chihiro Mochizuki, Yukihito Kayabe, Junna Nakamura, Masaya Igase, Takuya Mizuno, Michihiro Nakamura.
Surface Functionalization of Organosilica Nanoparticles With Au Nanoparticles Inhibits Cell Proliferation and Induces Cell Death in 4T1 Mouse Mammary Tumor Cells for DNA and Mitochondrial-Synergized Damage in Radiotherapy .
Frontiers in Chemistry, 2022, 10, 907642.
( DOI: 10.3389/fchem.2022.907642)
【特許出願】(産学連携)
春田 知洋、中村 教泰
「観察方法およびマーカー」 (特願2022-53918)(出願日: 2022/3/29)
【学会会報(和文)】
望月 ちひろ, 中村 純奈, 中村 教泰
Au(I)- チオラート錯体含有発光チオール有機シリカナノ粒子の 合成と蛍光顕微鏡イメージング
への応用
ナノ学会会報 (The Bulletin of the Society of Nano Science and Technology) 2022, 20(2), 51-57.
【原著論文・英文】
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura.
Photostable and Biocompatible Luminescent Thiol-Terminated Organosilica Nanoparticles with Embedded Au(I)–Thiolate Complexes for Fluorescent Microscopic Imaging.
ACS Applied Nano Materials, 2021, 4(12) 13305-13318.
( DOI: 10.1021/acsanm.1c02826)
【原著論文・英文】(国際共著)
Aziz Awaad, Michihiro Nakamura.
Size-dependent biodistribution of thiol-organosilica nanoparticles and F4/80 protein expression in the genital tract of female mice after intravaginal administration.
Histochemistry and Cell Biology, 2021, 155(6) 683-698.
( DOI: 10.1007/s00418-021-01974-1., PubMed: 33656583 )
【原著論文・英文】(国際共著)
Hyungjin Kim, Daniel Röth, Yasuhiro Isoe, Koichiro Hayashi, Chihiro Mochizuki, Kalkum Markus, Michihiro Nakamura.
Protein Corona Components of Polyethylene Glycol-conjugated Organosilica Nanoparticles Modulates Macrophage Uptake.
Colloids and Surfaces B: Biointerfaces, 2021, 199, 111527.
( DOI: 10.1016/j.colsurfb.2020.111527., PubMed: 33387796 )
【総説・英文】
Chihiro Mochizuki, Junna Nakamura, Michihiro Nakamura.
Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics.
Biomedicines, 2021, 9(1), 73.
( DOI: 10.3390/biomedicines9010073., PubMed: 33451074 )
【原著論文・英文】
Michihiro Nakamura, Koichiro Hayashi, Junna Nakamura, Chihiro Mochizuki,
Takuya Murakami, Hirokazu Miki, Shuji Ozaki, Masahiro Abe.
Near-Infrared Fluorescent Thiol-Organosilica Nanoparticles That Are
Functionalized with IR-820 and Their Applications for Long-Term Imaging
of in Situ Labeled Cells and Depth-Dependent Tumor in Vivo Imaging.
Chemistry of Materials, 2020, 32(17), 7201-14.
( DOI: 10.1021/10.1021/acs.chemmater.0c01414.)
【プレスリリース】
「革新技術！ 体外からがん組織を深部まで観察できる近赤外蛍光・有機シリカナノ粒子の作製に成功」
【山口大学プレスリリース】
