メンバー

研究内容

心房細動に対するカテーテルアブレーションにおいて、コンタクトフォースカテーテル、クライオバルーン、ホットバルーン、レーザーバルーンといった新規デバイスの成績・特徴・合併症等を評価し、また心房細動に対する抗凝固療法、心機能との関連についても吉賀を中心に研究してきました。現在は2024年に本邦に導入されたパルスフィールドカテーテルによるアブレーションの特徴についての研究を開始しています。心房細動に対するカテーテルアブレーションの成績、治療ストラテジーの構築、リモデリング抑制、血栓形成との関連等は吉賀・小室を中心に、また上大静脈と心房細動との関連は吉賀・久岡を中心に、長期予後や血行動態との関連は吉賀・石口を中心に心房細動診療に関して総合的に研究しています。研究成果は世界最大の循環器学会であるEuropean Society of Cardiologyによる心房細動ガイドライン(2024年版)や、関連学会合同での心房細動カテーテルアブレーションへのエキスパートコンセンサス(2024年版)にも引用されています。房室結節回帰性頻拍におけるHigh-resolution mappingを用いた機序解明について大学院生の橋本が研究を開始しました。突然死や遺伝性不整脈、 デバイス治療、遠隔モニタリング等、より適切な治療選択とその有効性評価に関して福田を中心に研究を行っています。また、基礎研究に関しては大野がUniversity of Kentuckyに留学後帰学し細胞生理や概日リズムを中心とした研究を行っています。

　　　ESC Heart Fail. 2022                   　　Eur Heart J Cardiovasc Imaging. 2022

多施設共同研究

現在進行中

New JCDTR、J-IVF、J-ABレジストリー、J-LEX、J-WCDRなど

これまで携わってきた研究

Expand研究、ANAFIEレジストリー、SAFE-A試験、J-ELD AF試験、KYU-RABLE研究 、HARVEST研究、 HINODE研究、MIYABI試験、EMPA-ICD

研究実績（英文論文）

Ishiguchi H, Yoshiga Y, Shimizu A, Fukuda M, Omuro A, Hisaoka M, Nakashima Y, Fujita M, Hashimoto S, Omuro T, Ariyoshi T, Kobayashi S, Okamura T, Sano M. Novel Method for Risk Stratification of Major Adverse Clinical Events Using Pre- and Post-Ablation Left Atrial Volume Index in Patients With Persistent Atrial Fibrillation. Circ Rep. 2024;6:415-423. doi: 10.1253/circrep.

Uchida T, Ishiguchi H, Ariyoshi T, Fujita M, Fukuda M, Wada Y, Yoshiga Y, Okamura T, Yano M. Chronic Expanding Hematoma in Device Pocket Developing 5 Years After Implantation. Circ Rep. 2023;5:95-96. doi: 10.1253/circrep.CR-22-0128

Ishiguchi H, Yoshiga Y, Okamura T, Yano M. Abnormal mosaic flow in the left atrium observed from a parasternal long-axis view in a patient with a history of pulmonary vein isolation: a case report. Eur Heart J Case Rep. 2023;7:ytad067. doi: 10.1093/ehjcr/ytad067.

Ishiguchi H, Yoshiga Y, Shimizu A, Fukuda M, Hisaoka M, Hashimoto S, Omuro T, Okamura T, Kobayashi S, Yano M. Association between the atrial tachyarrhythmia recurrence period and long-term major adverse clinical events following catheter ablation for atrial fibrillation. Int J Cardiol Heart Vasc. 2023;47:101228. doi: 10.1016/j.ijcha.2023.101228

Nawata J, Ishiguchi H, Yoshiga Y, Wada Y, Yano M. Iatrogenic tricuspid regurgitation after ablation for premature ventricular contraction originating near the right bundle branch. Eur Heart J Cardiovasc Imaging. 2022;23:e494. doi: 10.1093/ehjci/jeac165.

Ishiguchi H, Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Kato T, Fujii S, Hisaoka M, Uchida T, et al. Impact of Atrial Tachyarrhythmia Recurrence on the Development of Long-Term Adverse Clinical Events Following Catheter Ablation in Patients With Atrial Fibrillation With Systolic Impairment: A Single-Center Observational Study. J Am Heart Assoc. 2022;11:e023640. doi: 10.1161/JAHA.121.023640

Ishiguchi H, Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Kato T, Fujii S, Hisaoka M, Uchida T, et al. The Differential Prognostic Impact of Long-Duration Atrial High-Rate Episodes Detected by Cardiac Implantable Electronic Devices between Patients with and without a History of Atrial Fibrillation. J Clin Med. 2022;11. doi: 10.3390/jcm11061732

Ishiguchi H, Yoshiga Y, Shimizu A, Ueyama T, Fukuda M, Kato T, Fujii S, Hisaoka M, Uchida T, Omuro T, et al. Long-term events following catheter-ablation for atrial fibrillation in heart failure with preserved ejection fraction. ESC Heart Fail. 2022;9:3505-3518. doi: 10.1002/ehf2.14079

Ishiguchi H, Kaneyuki K, Yoshiga Y, Fukuda M, Okamura T, Yano M. Paroxysmal Atrioventricular Block in a Patient With Pacemaker Following Long-Distance Casting During Sea Fishing. Circ J. 2022;86:1143. doi: 10.1253/circj.CJ-21-1028

Omuro T, Yoshiga Y, Ueyama T, Shimizu A, Ono M, Fukuda M, Kato T, Ishiguchi H, Fujii S, Hisaoka M, et al. An impact of superior vena cava isolation in non-paroxysmal atrial fibrillation patients with low voltage areas. J Arrhythm. 2021;37:965-974. doi: 10.1002/joa3.12552

Ishiguchi H, Shimizu A, Ishikura M, Yoshida M, Imoto K, Sonoyama K, Kawabata T, Sugamori T, Ogawa M, Uchida T, Nakamura T, Morimoto T, Yasuda Y, Tanabe K, Yoshiga Y, Okamura T, Kobayashi S, Yano M, Oda T. Association Between Atrial High-Rate Episodes and Ischemic/Major Bleeding Events in Patients With a Cardiac Implantable Electronic Device – A 10-Year, Single-Center Historical Cohort Study. Circ J. 2021;85(8):1329-1337.

Ishiguchi H, Ishikura M, Yoshida M, Imoto K, Sonoyama K, Kawabata T, Ishihara Y, Yoshiga Y, Shimizu A, Oda T. Incidence and risk factors for cardiac implantable electronic device infection in current clinical settings in a Japanese population: A 20-year single-center observational study. J Cardiol. 2020;76(1):115-122.

Ishiguchi H, Yoshida M, Ishikura M, Kawabata T, Oda T. Successful ablation of biatrial tachycardia with preserved electrical activation of left atrial appendage by unidirectional connection via Bachmann’s bundle: A case report. Indian Pacing Electrophysiol J. 2020;20(4):166-169.

Ishiguchi H, Yoshida M, Kawabata T, Yoshiga Y, Shimizu A, Oda T. Delayed cardiac tamponade in catheter ablation for paroxysmal atrial fibrillation induced by a subacute hemorrhage. HeartRhythm Case Rep. 2020;6(7):419-422.

Yoshiga Y, Shimizu A, Yano M. The new era of atrial fibrillation treated by direct oral anticoagulants and catheter ablation-Comment on the “HAF-NET Registry”. J Arrhythm. 2019; 35: 709-710.

Yoshiga Y, Okamoto T, Shimizu A, Ueyama T, Ono M, Mito T, Fukuda M, Ishiguchi H, Omuro T, Kobayashi S, Goto A, Nishikawa J, Sakaida I, Yano M. Correlation between asymptomatic gastroesophageal excessive transmural injury after pulmonary vein isolation and a bonus freeze protocol using the second-generation 28-mm cryoballoon for paroxysmal atrial fibrillation. J Cardiol. 2019; 74: 494-500.

Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Fumimoto T, Ishiguchi H, Omuro T, Kobayashi S, Yano M. Strict sequential catheter ablation strategy targeting the pulmonary veins and superior vena cava for persistent atrial fibrillation. J Cardiol. 2018; 72: 128-134.

Ueyama T, Shimizu A, Yoshiga Y, Ono M, Fumimoto T, Yano M. Macroreentrant form of an adenosine 5′- triphosphate-sensitive atrial tachycardia arising from the vicinity of the atrioventricular node involving the tricuspid and mitral annuli as its reentrant circuit. HeartRhythm Case Rep. 2017;3:289-293.

Fumimoto T, Ueyama T, Shimizu A, Yoshiga Y, Ono M, Kato T, Ishiguchi H, Okamura T, Yamada J, Yano M. Inferior J waves in patients with vasospastic angina might be a risk factor for ventricular fibrillation. J Cardiol. 2017;70:271-277.

Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fumimoto T, Ishiguchi H, Yano M. Successful cryoballoon pulmonary vein isolation in a patient with situs inversus and dextrocardia. J Arrhythm. 2016;32:493-495.

Shimizu A, Omiya T, Ueyama T, Yoshiga Y, Doi M, Hiratsuka A, Fukuda M, Yoshida M, Matsuzaki M, Yano M. Effects of isoproterenol infusion on the ST segment and r of the QRS complex in the right precordial leads of the Brugada-type electrocardiogram pattern–author’s reply. J Cardiol. 2013;61:312-3.

Omiya T, Shimizu A, Ueyama T, Yoshiga Y, Doi M, Hiratsuka A, Fukuda M, Yoshida M, Matsuzaki M. Effects of isoproterenol and propranolol on the inducibility and frequency of ventricular fibrillation in patients with Brugada syndrome. J Cardiol. 2012;60:47-54.

Hiratsuka A, Shimizu A, Ueyama T, Yoshiga Y, Doi M, Ohmiya T, Yoshida M, Fukuda M, Matsuzaki M. Characteristics of induced ventricular fibrillation cycle length in symptomatic Brugada syndrome patients. Circ J. 2012;76:624-33.

Sugi N, Shimizu A, Ueyama T, Yoshiga Y, Doi M, Ohmiya T, Ohno M, Yoshida M, Matsuzaki M. What variables were associated with the inducibility of ventricular fibrillation during electrophysiologic stimulation test in patients without apparent organic heart disease? J Cardiol. 2010;56:35-43.

Sawa A, Shimizu A, Ueyama T, Yoshiga Y, Suzuki S, Sugi N, Oono M, Oomiya T, Matsuzaki M. Activation patterns and conduction velocity in posterolateral right atrium during typical atrial flutter using an electroanatomic mapping system. Circ J. 2008 Mar;72:384-91.

Ueyama T, Shimizu A, Esato M, Yoshiga Y, Sawa A, Suzuki S, Sugi N, Matsuzaki M. Pilsicainide-induced Brugada-type ECG and ventricular arrhythmias originating from the left posterior fascicle in a case with Brugada syndrome associated with idiopathic left ventricular tachycardia. Europace. 2008;10:86-90.

Shimizu A, Ueyama T, Yoshiga Y, Sawa A, Suzuki S, Sugi N, Matsuzaki M. Spectral analysis of atrial fibrillation cycle lengths: comparison between fast Fourier transform analysis and autocorrelation function analysis using multipurpose physio-informatic analysis software. Circ J. 2007;71:242-51.

Ueyama T, Shimizu A, Yamagata T, Esato M, Ohmura M, Yoshiga Y, Kanemoto M, Kametani R, Sawa A, Suzuki S, Sugi N, Matsuzaki M. Different effect of the pure Na+ channel-blocker pilsicainide on the ST- segment response in the right precordial leads in patients with normal left ventricular function. Circ J. 2007;71:57-62.

Ueyama T, Shimizu A, Esato M, Kanemoto M, Kametani R, Sawa A, Suzuki S, Matsuzaki M. A case of a concealed type of Brugada syndrome with a J wave and mild ST-segment elevation in the inferolateral leads. J Electrocardiol. 2007;40:39-42.

Kanemoto M, Shimizu A, Yamagata T, Esato M, Ueyama T, Yoshiga Y, Kakugawa H, Kametani R, Inoue N, Sawa A, Matsuzaki M. Differentiation of the electrophysiological effects on the atrial myocardium between the pure Na channel blocker, pilsicainide, and flecainide. Cardiovasc Drugs Ther. 2004;18:295-303.

Kakugawa H, Shimizu A, Yamagata T, Esato M, Ueyama T, Yoshiga Y, Kanemoto M, Matsuzaki M. Decrease in the spatial dispersion at the termination of atrial fibrillation by intravenous cibenzoline. Circ J. 2003;67:810-5.

Shimizu A, Yamagata T, Esato M, Doi M, Kakugawa H, Kametani R, Inoue N, Kanemoto M,Matsuzaki M. New method of determining the atrial fibrillation cycle length during human atrial fibrillation. J Cardiovasc Electrophysiol. 2003;14:965-70.

Yoshiga Y, Shimizu A, Yamagata T, Esato M, Ueyama T, Ohmura M, Itagaki K, Kimura M, Kakugawa H, Doi M, Matsuzaki M. Effects of flecainide on the electrophysiological properties of atrial vulnerability in humans. Circ J. 2003;67:437-42.

Yoshiga Y, Shimizu A, Yamagata T, Hayano T, Ueyama T, Ohmura M, Itagaki K, Kimura M,Matsuzaki M. Beta-blocker decreases the increase in QT dispersion and transmural dispersion of repolarization induced by bepridil. Circ J. 2002;66:1024-8.

Shimizu A, Yamagata T, Yoshiga Y, Hayano T, Ohmura M, Kimura M, Itagaki K, Matsuzaki M. Double ventricular response by a single ventricular extrastimulus to the inner loop of reentry in a patient without apparent heart disease. Pacing Clin Electrophysiol. 2000;23:1691-4.

Yamagata T, Shimizu A, Ueyama T, Hayano T, Esato M, Tatsuno H, Ohmura M, Tamura K,Matsuzaki M. Assessment of right artrial mapping and P wave-triggered signal-average in patients with paroxysmal atrial fibrillation. J Electrocardiol. 1999;32:243-51.

Hayano T, Shimizu A, Ikeda Y, Yamamoto T, Yamagata T, Ueyama T, Furutani Y, Matsuzaki M. Paradoxical effects of pirenzepine on parasympathetic activity in chronic heart failure and control. Int J Cardiol. 1999;68:47-56.

Esato M, Shimizu A, Chun YH, Tatsuno H, Yamagata T, Matsuzaki M. Electrophysiologic effects of a class I antiarrhythmic agent, cibenzoline, on the refractoriness and conduction of the human atrium in vivo. J Cardiovasc Pharmacol. 1996;28:321-7.